Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1

Keyphrases

• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• Antiviral Activity 100%
• Vaginal Microbicides 100%
• Hydroxypropyl Methylcellulose 100%
• Pyrimidinedione 100%
• Dual Mechanism of Action 100%
• Microbicide Gel 100%
• Gel Formulation 66%
• Safety Assessment 66%
• Cellulose Gel 66%
• Therapeutic Window 33%
• Inflammatory Response 33%
• Cell Viability 33%
• Novel Class 33%
• Culture Media 33%
• In Vivo Model 33%
• HIV Infection 33%
• Chemical Stability 33%
• Alternative Formulations 33%
• Stability Study 33%
• Microbicides 33%
• Mechanical Stability 33%
• Sustained Delivery 33%
• Lag Time 33%
• Inhibition Assay 33%
• Drug Release Profile 33%
• Significant Loss 33%
• Activity Evaluation 33%
• Entry Inhibitor 33%
• Nanomolar Concentrations 33%
• Complete Protection 33%
• Vaginal Gel 33%
• Formulation Development 33%
• Effective Concentration 33%
• HIV Entry 33%
• Lead Molecules 33%
• Physiologically Relevant Conditions 33%
• Diffusion Controlled Release 33%
• In Vitro Release Study 33%
• Accelerated Condition 33%
• Carbopol 33%

Pharmacology, Toxicology and Pharmaceutical Science

• HIV 100%
• Antiviral Activity 100%
• Hydroxyethyl Cellulose 100%
• Antimicrobial Agent 100%
• Drug Release 33%
• Chemical Stability 33%
• Controlled Release 33%
• Cell Viability 33%
• Human Immunodeficiency Virus Infection 33%
• Carbomer 33%
• Inflammation 33%
• Therapeutic Window 33%
• EC50 33%