Abstract
Our objective was to evaluate valaciclovir for anogenital herpes in HIV-infected individuals using 2 controlled trials conducted before highly active antiretroviral therapy (HAART) was used. In Study 1, 1062 patients (CD4+ ≥ 100cells/mm3) received suppressive valaciclovir or aciclovir for one year and were assessed monthly. In Study 2, 467 patients were treated episodically for ≥5days with valaciclovir or aciclovir and evaluated daily. Valaciclovir was as effective as aciclovir for suppression and episodic treatment of herpes. Hazard ratios [95% confidence interval (CI)] for time to recurrence for valaciclovir 500mg twice daily and 1000mg once daily vs aciclovir were 0.73 [0.50, 1.06], P=0.10, and 1.31 [0.94, 1.82], P=0.11. Valaciclovir 500mg twice daily was superior to 1000mg once daily, P=0.001. Valaciclovir 1000 mg twice daily was comparable to aciclovir on herpes episode duration (hazard ratio 0.92 [0.75, 1.14]). Adverse events were similar among treatments. In conclusion, valaciclovir is a safe, effective, convenient alternative to aciclovir for HSV infection in HIV-infected individuals.
Original language | English (US) |
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Pages (from-to) | 12-21 |
Number of pages | 10 |
Journal | International Journal of STD and AIDS |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - 2002 |
Keywords
- HIV
- Herpes simplex virus
- Recurrent genital herpes
- Valaciclovir
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Pharmacology (medical)
- Infectious Diseases
- Dermatology