Validation of a Mathematical Model of Bidirectional Glenn Circulation With Aortopulmonary Collaterals and the Implications for QP/QS Calculation

Zhe A. Fang, Sunil J. Ghelani, Sophia Koutsogiannaki, James A. DiNardo, Koichi Yuki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objectives: A mathematical model of the oxygen delivery kinetics of the bidirectional Glenn (BDG) shunt circulation incorporating aortopulmonary collateral (APC) flow was created. The model was used to characterize oxygen delivery and compare modeled data to actual patient data obtained using cardiac magnetic resonance imaging (MRI) and catheterization. In addition, cardiac MRI and catheterization assessment of pulmonary blood flow in the presence of APC flow were compared. Design: Mathematical model and retrospective data analysis of patients who underwent cardiac MRI and catheterization. The mathematical model is based on the concept that APC flow to the lungs is recirculated pulmonary venous blood flow, which does not contribute to systemic oxygen delivery. Setting: Single-center, university teaching hospital. Participants: The study included 98 patients with BDG shunt undergoing cardiac MRI and cardiac catheterization. Measurements and Main Results: In the absence of APC flow, the pulmonary blood flow to systemic blood flow ratio (Qp/Qs) calculated using cardiac catheterization data closely matched that obtained with cardiac MRI. In the presence of APC flow, Qp/Qs calculated using cardiac catheterization data systematically underestimated values obtained with cardiac MRI. A mathematical model of BDG shunt oxygen delivery incorporating variable APC flow was created. The model provided reasonable prediction of actual patient data for arterial blood oxygen, superior vena cava oxygen saturation, and oxygen delivery obtained at the time of cardiac catheterization in patients. Conclusion: The oxygen delivery kinetics of a BDG shunt incorporating variable APC flow can be modeled mathematically. Model output can be used to predict blood oxygen saturation after coil embolization of APC flow in the cardiac catheterization laboratory.

Original languageEnglish (US)
Pages (from-to)395-401
Number of pages7
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume32
Issue number1
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • Qp/Qs
  • aortopulmonary collateral
  • bidirectional Glenn
  • cardiac catheterization
  • cardiac magnetic resonance imaging
  • mathematical model
  • single ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine

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