@article{67ede53a0b834783acdfac9ed0f640eb,
title = "Validation of association of the apolipoprotein e ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants",
abstract = "Objective Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects (CHD) in infancy. Replication of this finding in an independent cohort is essential to validate the observed genotype-phenotype association.Conclusions These data validate the association of the APOE ε2 allele with adverse early ND outcomes after cardiac surgery in infants, independent of patient and operative factors. Genetic variants that decrease neuroresilience and impair neuronal repair after brain injury are important risk factors for ND dysfunction after surgery for CHD.Results Complete data were available for 298 of 435 patients. After adjustment for preoperative and postoperative covariates, the APOE ε2 allele was associated with a lower PDI score (P =.038). Patients with the ε2 allele had a PDI score approximately 6 points lower than those without the risk allele, explaining 1.04% of overall PDI variance, because the ε2 allele was present in only 11% of the patients. There was a marginal effect of the ε2 allele on MDI scores (P =.058).",
author = "Gaynor, {J. William} and Kim, {Daniel Seung} and Arrington, {Cammon B.} and Atz, {Andrew M.} and Bellinger, {David C.} and Burt, {Amber A.} and Ghanayem, {Nancy S.} and Jacobs, {Jeffery P.} and Lee, {Teresa M.} and Lewis, {Alan B.} and Mahle, {William T.} and Marino, {Bradley S.} and Miller, {Stephen G.} and Newburger, {Jane W.} and Christian Pizarro and Chitra Ravishankar and Santani, {Avni B.} and Wilder, {Nicole S.} and Jarvik, {Gail P.} and Seema Mital and Russell, {Mark W.}",
note = "Funding Information: The Infant Single Ventricle (ISV) trial was supported by the National Heart, Lung, and Blood Institute grants (NHLBI; HL068269 , HL068270 , HL068279 , HL068281 , HL068285 , HL068292 , HL068290 , HL068288 , and HL085057 ) and the Food and Drug Administration's Office of Orphan Products Development . Funding Information: The Single Ventricle Reconstruction (SVR) trial was supported by grants HL068269 , HL068270 , HL068279 , HL068281 , HL068285 , HL068288 , HL068290 , HL068292 , and HL085057 from the National Heart, Lung, and Blood Institute ; and with support from Harvard Catalyst / The Harvard Clinical and Translational Science Center (NIH Award UL1 RR 025758 and financial contributions from Harvard University and its affiliated academic health care centers). Funding Information: This study was supported by the Daniel M. Tabas Endowed Chair in Pediatric Cardiothoracic Surgery at The Children's Hospital of Philadelphia. D.S. Kim was funded by a grant from the National Institute of Mental Health ( 1F31MH101905-01 ). ",
year = "2014",
month = dec,
day = "1",
doi = "10.1016/j.jtcvs.2014.07.052",
language = "English (US)",
volume = "148",
pages = "2560--2568",
journal = "Journal of Thoracic and Cardiovascular Surgery",
issn = "0022-5223",
publisher = "Mosby Inc.",
number = "6",
}