Validation of doubly labeled water for measuring energy expenditure during parenteral nutrition

D. A. Schoeller, R. F. Kushner, P. J H Jones

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The doubly labeled water method was compared with intake-balance for measuring energy expenditure in five patients receiving total parenteral nutrition (TPN). Because parenteral solutions were isotopically different from local water, patients had to be placed on TPN at least 10 days before the metabolic period. Approximately 0.1 g 2H2O and 0.25 g H218O per kg total body water were given orally. We collected saliva before, 3 h, and 4 h after the dose for measurement of total body water and urine before, 1 day, and 14 days after the dose for measurement of isotope eliminations. On day 14, total body weight was remeasured and change in body energy stores was calculated, assuming constant hydration. Intake was assessed from weights of TPN fluids plus dietary record for any oral intake. Energy expenditure from doubly labeled water (±SD) averaged 3 ± 6% greater than intake-balance. Doubly labeled water method is a noninvasive, nonrestrictive method for measuring energy expenditure in patients receiving TPN.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume44
Issue number2
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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