Validation of eye-tracking measures of social attention as a potential biomarker for autism clinical trials

Michael Andrew Murias*, Samantha Major, Katherine Davlantis, Lauren Franz, Adrianne Harris, Benjamin Rardin, Maura Sabatos-DeVito, Geraldine Dawson

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Social communication impairments are a core feature of autism spectrum disorder (ASD), and this class of symptoms is a target for treatments for the disorder. Measures of social attention, assessed via eye-gaze tracking (EGT), have been proposed as an early efficacy biomarker for clinical trials targeting social communication skills. EGT measures have been shown to differentiate children with ASD from typical children; however, there is less known about their relationships with social communication outcome measures that are typically used in ASD clinical trials. In the present study, an EGT task involving viewing a videotape of an actor making bids for a child's attention was evaluated in 25 children with ASD aged 24–72 months. Children's attention to the actor during the dyadic bid condition measured via EGT was found to be strongly associated with five well-validated caregiver-reported outcome measures that are commonly used to assess social communication in clinical trials. These results highlight the convergent validity of EGT measures of social attention in relation to caregiver-reported clinical measures. EGT holds promise as a non-invasive, quantitative, and objective biomarker that is associated with social communication abilities in children with ASD. Autism Res 2018, 11: 166–174.

Original languageEnglish (US)
Pages (from-to)166-174
Number of pages9
JournalAutism Research
Volume11
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • autism spectrum disorder
  • biomarker
  • clinical trials
  • eye movement
  • eye-tracking

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Genetics(clinical)

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    Murias, M. A., Major, S., Davlantis, K., Franz, L., Harris, A., Rardin, B., Sabatos-DeVito, M., & Dawson, G. (2018). Validation of eye-tracking measures of social attention as a potential biomarker for autism clinical trials. Autism Research, 11(1), 166-174. https://doi.org/10.1002/aur.1894