Validation of injection parameters for catheter-directed intraarterial gadolinium-enhanced MR angiography

Reed A. Omary*, Kevin P. Henseler, Orhan Unal, Randall J. Smith, Robert K. Ryu, Scott A Resnick, Mark B. Saker, Howard B Chrisman, Richard Frayne, J. Paul Finn, Debiao Li, Thomas M. Grist

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations


Rationale and Objectives. Catheter-directed intraarterial (IA) injections of gadolinium contrast agents may be used during endovascular interventions with magnetic resonance (MR) imaging guidance. Injection protocols require further validation. Using a flow phantom and swine, the authors aimed to (a) measure the optimal arterial gadolinium concentration ([Gd]) required for MR angiography and (b) validate a proposed IA injection protocol for gadolinium-enhanced MR angiography. Materials and Methods. For in vitro experiments, the authors placed a catheter in the aorta of an aorto-renal-iliac flow phantom. Injected [Gd], injection rates, and aortic blood flow rates were varied independently for 36 separate IA gadolinium injections. The authors performed 2D and 3D MR angiography with a fast spoiled gradient-recalled echo sequence. For subsequent in vivo experiments, they selectively placed catheters within the aorta, renal artery, or common iliac artery of three pigs. Injection rate and injected [Gd] were varied. The authors performed 32 separate IA gadolinium injections for 2D MR angiography. Signal-to-noise ratios (SNRs) were compared for the various combinations of injection rate and injected [Gd]. Results. In vitro, an arterial [Gd] of 2%-4% produced an optimal SNR for 2D MR angiography, and 3%-5% was best for 3D MR angiography. In swine, an arterial [Gd] of 1%-4% produced an optimal SNR. In the phantom and swine experiments, SNR was maintained at higher injection rates by inversely varying the injected [Gd]. Conclusion. Dilute arterial [Gd] is required for optimal IA gadolinium-enhanced MR angiography. To maintain an optimal SNR, injection rates and injected [Gd] should be varied inversely. The postulated injection protocol was validated.

Original languageEnglish (US)
Pages (from-to)172-185
Number of pages14
JournalAcademic Radiology
Issue number2
StatePublished - Jan 1 2002


  • Gadolinium
  • Magnetic resonance (MR), contrast enhancement
  • Magnetic resonance (MR), guidance
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Omary, R. A., Henseler, K. P., Unal, O., Smith, R. J., Ryu, R. K., Resnick, S. A., Saker, M. B., Chrisman, H. B., Frayne, R., Finn, J. P., Li, D., & Grist, T. M. (2002). Validation of injection parameters for catheter-directed intraarterial gadolinium-enhanced MR angiography. Academic Radiology, 9(2), 172-185.