Validation of Simplified Visual Acuity Testing Protocols in Amyotrophic Lateral Sclerosis

Lindsay C. Boven; Qin Li Jiang; Heather E. Moss

doi:10.1080/01658107.2017.1305422

Validation of Simplified Visual Acuity Testing Protocols in Amyotrophic Lateral Sclerosis

Lindsay C. Boven, Qin Li Jiang, Heather E. Moss^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS (n = 10) and control (n = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0.83 to 0.98 (HCVA, excellent agreement) and 0.56 to 0.75 (LCVA, moderate agreement). Differences between LCVA and GS protocols exceeded test-retest reliability. Simplified HCVA protocols using LCD (liquid crystal display) tablet charts and/or pinhole correction produced valid measurements. None of the modified LCVA testing protocols produced valid measurements.

Original language	English (US)
Pages (from-to)	247-252
Number of pages	6
Journal	Neuro-Ophthalmology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1080/01658107.2017.1305422
State	Published - Sep 3 2017
Externally published	Yes

Keywords

Amyotrophic lateral sclerosis
LCD tablet
high-contrast visual acuity
low-contrast visual acuity
pinhole

ASJC Scopus subject areas

Clinical Neurology
Ophthalmology

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10.1080/01658107.2017.1305422

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title = "Validation of Simplified Visual Acuity Testing Protocols in Amyotrophic Lateral Sclerosis",

abstract = "High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS (n = 10) and control (n = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0.83 to 0.98 (HCVA, excellent agreement) and 0.56 to 0.75 (LCVA, moderate agreement). Differences between LCVA and GS protocols exceeded test-retest reliability. Simplified HCVA protocols using LCD (liquid crystal display) tablet charts and/or pinhole correction produced valid measurements. None of the modified LCVA testing protocols produced valid measurements.",

keywords = "Amyotrophic lateral sclerosis, LCD tablet, high-contrast visual acuity, low-contrast visual acuity, pinhole",

author = "Boven, {Lindsay C.} and Jiang, {Qin Li} and Moss, {Heather E.}",

note = "Funding Information: This work was supported by National Institutes of Health grants K12 EY 02147 and K23 EY 024345 and Research to Prevent Blindness Unrestricted awards to University of Illinois at Chicago Department of Ophthalmology and Visual Sciences and Stanford Department of Ophthalmology. King-Devick testing software was provided free of charge by the manufacturer. No funding agency was involved in the conceptualisation, design, implementation, or analysis of this study. Publisher Copyright: {\textcopyright} 2017 Taylor & Francis.",

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doi = "10.1080/01658107.2017.1305422",

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PY - 2017/9/3

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N2 - High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS (n = 10) and control (n = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0.83 to 0.98 (HCVA, excellent agreement) and 0.56 to 0.75 (LCVA, moderate agreement). Differences between LCVA and GS protocols exceeded test-retest reliability. Simplified HCVA protocols using LCD (liquid crystal display) tablet charts and/or pinhole correction produced valid measurements. None of the modified LCVA testing protocols produced valid measurements.

AB - High- and low-contrast visual acuity (HCVA, LCVA) are potential quantitative markers of neurological dysfunction in amyotrophic lateral sclerosis (ALS). The complex nature and duration of gold standard (GS) protocols precludes widespread use in neurology settings. This study compares simplified to GS visual acuity (VA) protocols. Monocular HCVA and LCVA were measured in ALS (n = 10) and control (n = 4) subjects using six protocols, varying by two chart and three refraction methods. Intraclass correlation coefficients between simplified and GS protocols ranged from 0.83 to 0.98 (HCVA, excellent agreement) and 0.56 to 0.75 (LCVA, moderate agreement). Differences between LCVA and GS protocols exceeded test-retest reliability. Simplified HCVA protocols using LCD (liquid crystal display) tablet charts and/or pinhole correction produced valid measurements. None of the modified LCVA testing protocols produced valid measurements.

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Validation of Simplified Visual Acuity Testing Protocols in Amyotrophic Lateral Sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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