Abstract
Objective: The Patient-Reported Outcomes Measurement Information System (PROMIS) aims to address the lack of generalizable and universal measure of patient-reported outcomes to assess health-related quality of life. It has not been validated for patients with chronic kidney disease. We aim to validate the PROMIS-57 and PROMIS-29 questionnaires among kidney transplant recipients. Methods: A cross-sectional sample of stable kidney transplant recipients was recruited. Each participant completed PROMIS-57, a 57-question instrument covering seven domains—physical function, anxiety, depression, fatigue, pain, sleep disturbance, and social functioning—alongside validated legacy questionnaires [Patient Health Questionnaire (PHQ9), General Anxiety Disorder (GAD7), Edmonton Symptom Assessment Scale revised (ESASr), and Kidney Disease Quality of Life (KDQoL-36)]. PROMIS-29, a 29-question instrument, is nested within PROMIS-57 and measures the same domains. Structural validity of PROMIS was assessed with confirmatory factor analysis, reported using the Comparative Fit Index (CFI). Construct validity was assessed with known-groups comparisons. Internal consistency was evaluated with Cronbach’s α and convergent validity was assessed with Spearman’s Rho. Test–retest reliability was assessed through the intraclass correlation coefficient (ICC). Results: Mean (± SD) age of the 177 participants was 50 (± 17), 57% were male and 55% Caucasian. Internal consistency of each domain was high (Cronbach’s α > 0.88). Confirmatory factor analysis showed good structural validity for most domains (CFI > 0.95, RMSEA < 0.05). Test–retest reliability indicated good agreement (ICC > 0.6). Known-groups comparisons by clinical and socio-demographic differences were found as hypothesized. Conclusions: Our results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience.
Original language | English (US) |
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Pages (from-to) | 815-827 |
Number of pages | 13 |
Journal | Quality of Life Research |
Volume | 28 |
Issue number | 3 |
DOIs | |
State | Published - Mar 15 2019 |
Keywords
- Kidney transplant
- PROMIS
- PROMIS-29
- PROMIS-57
- Patient-reported outcomes
- Renal transplant
- Validation study
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health