Abstract
Objective: The Patient-Reported Outcomes Measurement Information System (PROMIS) aims to address the lack of generalizable and universal measure of patient-reported outcomes to assess health-related quality of life. It has not been validated for patients with chronic kidney disease. We aim to validate the PROMIS-57 and PROMIS-29 questionnaires among kidney transplant recipients. Methods: A cross-sectional sample of stable kidney transplant recipients was recruited. Each participant completed PROMIS-57, a 57-question instrument covering seven domains—physical function, anxiety, depression, fatigue, pain, sleep disturbance, and social functioning—alongside validated legacy questionnaires [Patient Health Questionnaire (PHQ9), General Anxiety Disorder (GAD7), Edmonton Symptom Assessment Scale revised (ESASr), and Kidney Disease Quality of Life (KDQoL-36)]. PROMIS-29, a 29-question instrument, is nested within PROMIS-57 and measures the same domains. Structural validity of PROMIS was assessed with confirmatory factor analysis, reported using the Comparative Fit Index (CFI). Construct validity was assessed with known-groups comparisons. Internal consistency was evaluated with Cronbach’s α and convergent validity was assessed with Spearman’s Rho. Test–retest reliability was assessed through the intraclass correlation coefficient (ICC). Results: Mean (± SD) age of the 177 participants was 50 (± 17), 57% were male and 55% Caucasian. Internal consistency of each domain was high (Cronbach’s α > 0.88). Confirmatory factor analysis showed good structural validity for most domains (CFI > 0.95, RMSEA < 0.05). Test–retest reliability indicated good agreement (ICC > 0.6). Known-groups comparisons by clinical and socio-demographic differences were found as hypothesized. Conclusions: Our results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 815-827 |
| Number of pages | 13 |
| Journal | Quality of Life Research |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 15 2019 |
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Keywords
- Kidney transplant
- PROMIS
- PROMIS-29
- PROMIS-57
- Patient-reported outcomes
- Renal transplant
- Validation study
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
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Validation of the Patient-Reported Outcomes Measurement Information System (PROMIS)-57 and -29 item short forms among kidney transplant recipients. / Tang, Evan; Ekundayo, Oladapo; Peipert, John Devin; Edwards, Nathaniel; Bansal, Aarushi; Richardson, Candice; Bartlett, Susan J.; Howell, Doris; Li, Madeline; Cella, David; Novak, Marta; Mucsi, Istvan.
In: Quality of Life Research, Vol. 28, No. 3, 15.03.2019, p. 815-827.Research output: Contribution to journal › Article
TY - JOUR
T1 - Validation of the Patient-Reported Outcomes Measurement Information System (PROMIS)-57 and -29 item short forms among kidney transplant recipients
AU - Tang, Evan
AU - Ekundayo, Oladapo
AU - Peipert, John Devin
AU - Edwards, Nathaniel
AU - Bansal, Aarushi
AU - Richardson, Candice
AU - Bartlett, Susan J.
AU - Howell, Doris
AU - Li, Madeline
AU - Cella, David
AU - Novak, Marta
AU - Mucsi, Istvan
PY - 2019/3/15
Y1 - 2019/3/15
N2 - Objective: The Patient-Reported Outcomes Measurement Information System (PROMIS) aims to address the lack of generalizable and universal measure of patient-reported outcomes to assess health-related quality of life. It has not been validated for patients with chronic kidney disease. We aim to validate the PROMIS-57 and PROMIS-29 questionnaires among kidney transplant recipients. Methods: A cross-sectional sample of stable kidney transplant recipients was recruited. Each participant completed PROMIS-57, a 57-question instrument covering seven domains—physical function, anxiety, depression, fatigue, pain, sleep disturbance, and social functioning—alongside validated legacy questionnaires [Patient Health Questionnaire (PHQ9), General Anxiety Disorder (GAD7), Edmonton Symptom Assessment Scale revised (ESASr), and Kidney Disease Quality of Life (KDQoL-36)]. PROMIS-29, a 29-question instrument, is nested within PROMIS-57 and measures the same domains. Structural validity of PROMIS was assessed with confirmatory factor analysis, reported using the Comparative Fit Index (CFI). Construct validity was assessed with known-groups comparisons. Internal consistency was evaluated with Cronbach’s α and convergent validity was assessed with Spearman’s Rho. Test–retest reliability was assessed through the intraclass correlation coefficient (ICC). Results: Mean (± SD) age of the 177 participants was 50 (± 17), 57% were male and 55% Caucasian. Internal consistency of each domain was high (Cronbach’s α > 0.88). Confirmatory factor analysis showed good structural validity for most domains (CFI > 0.95, RMSEA < 0.05). Test–retest reliability indicated good agreement (ICC > 0.6). Known-groups comparisons by clinical and socio-demographic differences were found as hypothesized. Conclusions: Our results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience.
AB - Objective: The Patient-Reported Outcomes Measurement Information System (PROMIS) aims to address the lack of generalizable and universal measure of patient-reported outcomes to assess health-related quality of life. It has not been validated for patients with chronic kidney disease. We aim to validate the PROMIS-57 and PROMIS-29 questionnaires among kidney transplant recipients. Methods: A cross-sectional sample of stable kidney transplant recipients was recruited. Each participant completed PROMIS-57, a 57-question instrument covering seven domains—physical function, anxiety, depression, fatigue, pain, sleep disturbance, and social functioning—alongside validated legacy questionnaires [Patient Health Questionnaire (PHQ9), General Anxiety Disorder (GAD7), Edmonton Symptom Assessment Scale revised (ESASr), and Kidney Disease Quality of Life (KDQoL-36)]. PROMIS-29, a 29-question instrument, is nested within PROMIS-57 and measures the same domains. Structural validity of PROMIS was assessed with confirmatory factor analysis, reported using the Comparative Fit Index (CFI). Construct validity was assessed with known-groups comparisons. Internal consistency was evaluated with Cronbach’s α and convergent validity was assessed with Spearman’s Rho. Test–retest reliability was assessed through the intraclass correlation coefficient (ICC). Results: Mean (± SD) age of the 177 participants was 50 (± 17), 57% were male and 55% Caucasian. Internal consistency of each domain was high (Cronbach’s α > 0.88). Confirmatory factor analysis showed good structural validity for most domains (CFI > 0.95, RMSEA < 0.05). Test–retest reliability indicated good agreement (ICC > 0.6). Known-groups comparisons by clinical and socio-demographic differences were found as hypothesized. Conclusions: Our results provide evidence that PROMIS-57 and PROMIS-29 are highly reliable and valid instruments among kidney transplant recipients. We propose it as a valuable tool to assess important domains of the illness experience.
KW - Kidney transplant
KW - PROMIS
KW - PROMIS-29
KW - PROMIS-57
KW - Patient-reported outcomes
KW - Renal transplant
KW - Validation study
UR - http://www.scopus.com/inward/record.url?scp=85057202268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85057202268&partnerID=8YFLogxK
U2 - 10.1007/s11136-018-2058-2
DO - 10.1007/s11136-018-2058-2
M3 - Article
C2 - 30467780
AN - SCOPUS:85057202268
VL - 28
SP - 815
EP - 827
JO - Quality of Life Research
JF - Quality of Life Research
SN - 0962-9343
IS - 3
ER -