Validation of the Pediatric Automated Neuropsychological Assessment Metrics in childhood-onset systemic lupus erythematosus.

Hermine I. Brunner*, Marisa S. Klein-Gitelman, Frank Zelko, Erin C. Thomas, Jessica Hummel, Shannen M. Nelson, Jennifer Huggins, Megan L. Curran, Tresa Roebuck-Spencer, Dean W. Beebe, Jun Ying

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

To evaluate the reproducibility and validity of the Pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) when used in childhood-onset systemic lupus erythematosus (cSLE). Forty children with cSLE and 40 matched controls were followed for up to 18 months. Formal neuropsychological testing at baseline was repeated after 18 months of followup; overall cognitive performance and domain-specific cognition (attention, working memory, processing speed, and visuoconstructional ability) were measured and categorized as normal cognition, mild/moderate, or moderate/severe impairment. The 10 Ped-ANAM subtests were completed every 6 months and twice at baseline. Ped-ANAM performance was based on accuracy (AC), mean time to correct response (MNc), throughput, and coefficient of variation of the time required for a correct response (CVc) as a measure of response consistency. Particularly, MNc scores demonstrated moderate to substantial reproducibility (intraclass correlation coefficients 0.47-0.80). Means of select Ped-ANAM scores (MNc, AC, CVc) differed significantly between children with different levels of cognitive performance and allowed for the detection of moderate or severe cognitive impairment with 100% sensitivity and 86% specificity. Six Ped-ANAM subtests significantly correlated with the change in overall cognitive function in cSLE (baseline versus 18 months; Spearman's correlation coefficient >0.4, P < 0.05; n = 24). The Ped-ANAM has moderate to substantial reproducibility, criterion and construct validity, and may be responsive to change in cSLE. Additional research is required to confirm the outstanding accuracy of the Ped-ANAM in identifying cognitive impairment, as well as its usefulness in detecting clinically relevant changes in cognition over time.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalUnknown Journal
Volume65
Issue number3
DOIs
StatePublished - Mar 2013

ASJC Scopus subject areas

  • Rheumatology

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    Brunner, H. I., Klein-Gitelman, M. S., Zelko, F., Thomas, E. C., Hummel, J., Nelson, S. M., Huggins, J., Curran, M. L., Roebuck-Spencer, T., Beebe, D. W., & Ying, J. (2013). Validation of the Pediatric Automated Neuropsychological Assessment Metrics in childhood-onset systemic lupus erythematosus. Unknown Journal, 65(3), 372-381. https://doi.org/10.1002/acr.21835