Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients

Roxanne E. Jensen, Arnold L. Potosky, Bryce B. Reeve, Elizabeth A Hahn, David Cella, James Fries, Ashley Wilder Smith, Theresa H.M. Keegan, Xiao Cheng Wu, Lisa Paddock, Carol M. Moinpour

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.

Original languageEnglish (US)
Pages (from-to)2333-2344
Number of pages12
JournalQuality of Life Research
Volume24
Issue number10
DOIs
StatePublished - Oct 14 2015

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Information Systems
Population
Neoplasms
Age Groups
Marital Status
Reproducibility of Results
Cervix Uteri
Non-Hodgkin's Lymphoma
Fatigue
Comorbidity
Prostate
Lung Neoplasms
Breast
Research Personnel
Demography
Patient Reported Outcome Measures
Education
Pain
Health

Keywords

  • Oncology
  • Patient-reported outcomes
  • Physical function
  • Validation studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Jensen, Roxanne E. ; Potosky, Arnold L. ; Reeve, Bryce B. ; Hahn, Elizabeth A ; Cella, David ; Fries, James ; Smith, Ashley Wilder ; Keegan, Theresa H.M. ; Wu, Xiao Cheng ; Paddock, Lisa ; Moinpour, Carol M. / Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients. In: Quality of Life Research. 2015 ; Vol. 24, No. 10. pp. 2333-2344.
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abstract = "Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.",
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Jensen, RE, Potosky, AL, Reeve, BB, Hahn, EA, Cella, D, Fries, J, Smith, AW, Keegan, THM, Wu, XC, Paddock, L & Moinpour, CM 2015, 'Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients', Quality of Life Research, vol. 24, no. 10, pp. 2333-2344. https://doi.org/10.1007/s11136-015-0992-9

Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients. / Jensen, Roxanne E.; Potosky, Arnold L.; Reeve, Bryce B.; Hahn, Elizabeth A; Cella, David; Fries, James; Smith, Ashley Wilder; Keegan, Theresa H.M.; Wu, Xiao Cheng; Paddock, Lisa; Moinpour, Carol M.

In: Quality of Life Research, Vol. 24, No. 10, 14.10.2015, p. 2333-2344.

Research output: Contribution to journalArticle

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T1 - Validation of the PROMIS physical function measures in a diverse US population-based cohort of cancer patients

AU - Jensen, Roxanne E.

AU - Potosky, Arnold L.

AU - Reeve, Bryce B.

AU - Hahn, Elizabeth A

AU - Cella, David

AU - Fries, James

AU - Smith, Ashley Wilder

AU - Keegan, Theresa H.M.

AU - Wu, Xiao Cheng

AU - Paddock, Lisa

AU - Moinpour, Carol M.

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.

AB - Purpose: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures in a diverse, population-based cancer sample. Methods: Cancer patients 6–13 months post-diagnosis (n = 4840) were recruited for the Measuring Your Health study. Participants were diagnosed between 2010 and 2013 with non-Hodgkin lymphoma or cancers of the colorectum, lung, breast, uterus, cervix, or prostate. Four PROMIS physical function short forms (4a, 6b, 10a, and 16) were evaluated for validity and reliability across age and race–ethnicity groups. Covariates included gender, marital status, education level, cancer site and stage, comorbidities, and functional status. Results: PROMIS physical function short forms showed high internal consistency (Cronbach’s α = 0.92–0.96), convergent validity (fatigue, pain interference, FACT physical well-being all r ≥ 0.68), and discriminant validity (unrelated domains all r ≤ 0.3) across survey short forms, age, and race–ethnicity. Known-group differences by demographic, clinical, and functional characteristics performed as hypothesized. Ceiling effects for higher-functioning individuals were identified on most forms. Conclusions: This study provides strong evidence that PROMIS physical function measures are valid and reliable in multiple race–ethnicity and age groups. Researchers selecting specific PROMIS short forms should consider the degree of functional disability in their patient population to ensure that length and content are tailored to limit response burden.

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