Valproate and carbamazepine increase prefrontal dopamine release by 5-HT(1A) receptor activation

Junji Ichikawa*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

The anticonvulsant mood stabilizers valproic acid (250, 500 but not 50 mg/kg) and carbamazepine (6, 12.5 but not 3 mg/kg) were found to increase extracellular dopamine levels in rat medial prefrontal cortex, but not nucleus accumbens. Increased prefrontal dopamine was completely abolished by the selective 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide (WAY100635, 0.05 mg/kg). Anticonvulsants and clozapine may share a common mood stabilizing mechanism since clozapine is reported to have mood stabilizing effects and increase prefrontal dopamine by 5-HT(1A) receptor activation. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)R1-R3
JournalEuropean Journal of Pharmacology
Volume380
Issue number1
DOIs
StatePublished - Sep 3 1999

Keywords

  • 5-HT(1A) receptor
  • Anticonvulsant mood stabilizer
  • Dopamine

ASJC Scopus subject areas

  • Pharmacology

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