Valproate in the treatment of seizures associated with propionic acidemia

B. Wolf, E. P. Paulsen, F. E. Dreifuss

Research output: Contribution to journalLetterpeer-review

6 Scopus citations


MacDermont et al. (1980) have described the uncomplicated efficacy of valproate in treating the seizures of 2 patients with nonketotic hyperglycinemia even though valproate elevates urinary and serum glycine concentrations in individuals with convulsive disorders. Recent observations of increased urinary propionate excretion as a metabolic consequence of valproate therapy in 2 patients with seizures seem to contraindicate its use in children with disorders of propionate metabolism. However, we have successfully and safely used valproate to control seizures in a patient with propionyl coenzyme A carboxylase deficiency, a disorder characterized by both hyperglycinemia and propionic acidemia. The patient, an 11-year-old boy, is described.

Original languageEnglish (US)
Pages (from-to)162-163
Number of pages2
Issue number1
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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