MacDermont et al. (1980) have described the uncomplicated efficacy of valproate in treating the seizures of 2 patients with nonketotic hyperglycinemia even though valproate elevates urinary and serum glycine concentrations in individuals with convulsive disorders. Recent observations of increased urinary propionate excretion as a metabolic consequence of valproate therapy in 2 patients with seizures seem to contraindicate its use in children with disorders of propionate metabolism. However, we have successfully and safely used valproate to control seizures in a patient with propionyl coenzyme A carboxylase deficiency, a disorder characterized by both hyperglycinemia and propionic acidemia. The patient, an 11-year-old boy, is described.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Jan 1 1981|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health