Abstract
MacDermont et al. (1980) have described the uncomplicated efficacy of valproate in treating the seizures of 2 patients with nonketotic hyperglycinemia even though valproate elevates urinary and serum glycine concentrations in individuals with convulsive disorders. Recent observations of increased urinary propionate excretion as a metabolic consequence of valproate therapy in 2 patients with seizures seem to contraindicate its use in children with disorders of propionate metabolism. However, we have successfully and safely used valproate to control seizures in a patient with propionyl coenzyme A carboxylase deficiency, a disorder characterized by both hyperglycinemia and propionic acidemia. The patient, an 11-year-old boy, is described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 162-163 |
| Number of pages | 2 |
| Journal | Pediatrics |
| Volume | 67 |
| Issue number | 1 |
| State | Published - Jan 1 1981 |
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health