Valproate therapy: Predisposition to bone fracture?

Steven G. Pavlakis*, Rebecca L. Chusid, David P. Roye, Douglas R. Nordli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A 13-year-old girl on valproate therapy had 20 fractures over a 4-year period between the ages of 5 years and 9 years. Once valproate was withdrawn, no further fractures occurred over the ensuing 4 years. Three other children manifested at least two fractures while on valproate antiepileptic therapy. These reports suggest that valproate, along with other known causes of demineralization (e.g., lack of exercise, diet, and genetic factors), predisposes patients to fractures.

Original languageEnglish (US)
Pages (from-to)143-144
Number of pages2
JournalPediatric neurology
Issue number2
StatePublished - Aug 1 1998

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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