Value of amniocentesis versus fetal tissue for cytogenetic analysis in cases of fetal demise

Ann E. Bryant Borders, Jessica Greenberg, Stacey Plaga, Megan Shepard-Hinton, Carin Yates, Sherman Elias, Lee P. Shulman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: Use of fetal tissue for cytogenetic analysis in cases of second- and third-trimester fetal demise frequently results in unacceptably high failure rates. We reviewed our ongoing use of amniocentesis prior to uterine evacuation to determine if this provided a better source of cells for cytogenetic analysis. Methods: We compared cytogenetic results using fetal tissues obtained following uterine evacuation to our ongoing use of amniotic fluid cell obtained by transabdominal amniocentesis prior to uterine evacuation from 2003 to 2008. Results: In 49 of the 63 cases evaluated by fetal tissue biopsies performed after uterine evacuation, a karyotypic analysis was obtained (77.8%). Among the 38 cases evaluated by amniocentesis, an amniotic fluid sample and fetal cytogenetic results were obtained in all 38 (100%) cases. Conclusion: Our findings indicate that amniocentesis is a more reliable source of cytogenetic information than fetal tissue in cases of second- and third-trimester fetal demise.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalFetal Diagnosis and Therapy
Volume26
Issue number2
DOIs
StatePublished - Oct 2009

Keywords

  • Amniocentesis
  • Cytogenetics
  • Fetal demise
  • Fetal tissue
  • Second-trimester fetal demise
  • Third-trimester fetal demise

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology

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