Valvular heart disease: Introduction, clinical pathogenesis, and management

Siri Kunchakarra, Jyothy Puthumana, Kameswari Maganti*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Valvular heart disease (VHD) is a common cardiac condition with a big impact on healthcare economics. The incidence of VHD had been increasing over the past few decades, likely due to aging population [1]; improved mortality outcomes with increased survival in patients with conditions such as ischemic heart disease, chronic kidney disease, inflammatory disease states, and oncologic patients; earlier diagnoses due to technologic advances in imaging tools; and iatrogenic valve disease such as prosthetic valve dysfunction [2]. It is important to have an in-depth understanding of the different types of VHD; the natural history; interplay between anatomic, genetic, and molecular mechanisms of specific VHD; impact of VHD on other organ systems; and advances in diagnostic and therapeutic options that will translate to improved patient outcomes [3].

Original languageEnglish (US)
Title of host publicationPathophysiology and Pharmacotherapy of Cardiovascular Disease
PublisherSpringer International Publishing
Number of pages35
ISBN (Electronic)9783319159614
ISBN (Print)9783319159607
StatePublished - Jan 1 2015


  • Aortic regurgitation
  • Aortic stenosis
  • Aortic valve disease
  • Mitral stenosis
  • Mitral valve disease
  • Pathogenesis
  • Rheumatic heart disease
  • Tricuspid valve disease
  • Valvular heart disease

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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