Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm3 (ACTG 175)

Janet L. Lathey; Michael D. Hughes; Susan A. Fiscus; Timothy Pi; J. Brooks Jackson; Suraiya Rasheed; Tarek Elbeik; Richard Reichman; Anthony Japour; Richard T. D'Aquila; Walter Scott; Brigitte P. Griffith; Scott M. Hammer; David A. Katzenstein

doi:10.1086/514250

Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm³ (ACTG 175)

Janet L. Lathey^*, Michael D. Hughes, Susan A. Fiscus, Timothy Pi, J. Brooks Jackson, Suraiya Rasheed, Tarek Elbeik, Richard Reichman, Anthony Japour, Richard T. D'Aquila, Walter Scott, Brigitte P. Griffith, Scott M. Hammer, David A. Katzenstein

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Virologic measurements are increasingly used to evaluate prognosis and treatment responses in human immunodeficiency virus (HIV) type 1 infection. Markers of HIV-1 replication, including infectious HIV-1 titer from peripheral blood mononuclear cells, serum HIV-1 p24 antigen, plasma HIV-1 RNA, CD4 cell numbers, and viral syncytium-inducing (SI) phenotype, were determined in 391 virology substudy participants in AIDS Clinical Trials Group study 175. The subjects had 200-500 CD4 cells/mm³. All markers of viral replication significantly correlated with one another and were inversely related to CD4 cell number. Disease progression to an AIDS-defining event or death or loss of >50% of CD4 cells was associated with infectious HIV-1 titer (P < .001), HIV-1 RNA (P < .001), and HIV-1 p24 antigen (P = .007). In multivariate proportional hazards models, p24 antigen was never significant when HIV-1 RNA level was included. In a model containing infectious HIV-1 titer (P = .038), HIV-1 RNA (P < .001), SI phenotype (P < .001), and CD4 cell number (P = .18), only the virologic parameters remained significantly associated with progression.

Original language	English (US)
Pages (from-to)	617-624
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	177
Issue number	3
DOIs	https://doi.org/10.1086/514250
State	Published - 1998

Funding

Received 20 May 1997; revised 29 September 1997. Presented in part: 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 1997 (abstract 543). Informed consent was obtained from all study participants. The study followed the human experimentation guidelines of the US Department of Health and Human Services. Grant support: NIH: AI-27670, AI-38858, and AI-36214 (to J.L.L.); AI-25868, VC-006, and RR-00046 (to S.A.F.); AI-65304 (to J.B.J.); AI-27658 and RR-0004 (to R.R.); AI-27659 and AI-29193 (to R.D.); and AI-27560 (to W.S.). Reprints or correspondence: Dr. Janet L. Lathey, Dept. of Pediatrics, University of California, San Diego, 9500 Gilman Dr., #0672, La Jolla, CA 92093-0672 ([email protected]). * Present affiliation: Abbott Laboratories, Abbott Park, Illinois.

ASJC Scopus subject areas

General Medicine

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10.1086/514250

Cite this

Lathey, J. L., Hughes, M. D., Fiscus, S. A., Pi, T., Brooks Jackson, J., Rasheed, S., Elbeik, T., Reichman, R., Japour, A., D'Aquila, R. T., Scott, W., Griffith, B. P., Hammer, S. M., & Katzenstein, D. A. (1998). Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm³ (ACTG 175). Journal of Infectious Diseases, 177(3), 617-624. https://doi.org/10.1086/514250

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title = "Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm3 (ACTG 175)",

abstract = "Virologic measurements are increasingly used to evaluate prognosis and treatment responses in human immunodeficiency virus (HIV) type 1 infection. Markers of HIV-1 replication, including infectious HIV-1 titer from peripheral blood mononuclear cells, serum HIV-1 p24 antigen, plasma HIV-1 RNA, CD4 cell numbers, and viral syncytium-inducing (SI) phenotype, were determined in 391 virology substudy participants in AIDS Clinical Trials Group study 175. The subjects had 200-500 CD4 cells/mm3. All markers of viral replication significantly correlated with one another and were inversely related to CD4 cell number. Disease progression to an AIDS-defining event or death or loss of >50% of CD4 cells was associated with infectious HIV-1 titer (P < .001), HIV-1 RNA (P < .001), and HIV-1 p24 antigen (P = .007). In multivariate proportional hazards models, p24 antigen was never significant when HIV-1 RNA level was included. In a model containing infectious HIV-1 titer (P = .038), HIV-1 RNA (P < .001), SI phenotype (P < .001), and CD4 cell number (P = .18), only the virologic parameters remained significantly associated with progression.",

author = "Lathey, {Janet L.} and Hughes, {Michael D.} and Fiscus, {Susan A.} and Timothy Pi and {Brooks Jackson}, J. and Suraiya Rasheed and Tarek Elbeik and Richard Reichman and Anthony Japour and D'Aquila, {Richard T.} and Walter Scott and Griffith, {Brigitte P.} and Hammer, {Scott M.} and Katzenstein, {David A.}",

note = "Funding Information: Received 20 May 1997; revised 29 September 1997. Presented in part: 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 1997 (abstract 543). Informed consent was obtained from all study participants. The study followed the human experimentation guidelines of the US Department of Health and Human Services. Grant support: NIH: AI-27670, AI-38858, and AI-36214 (to J.L.L.); AI-25868, VC-006, and RR-00046 (to S.A.F.); AI-65304 (to J.B.J.); AI-27658 and RR-0004 (to R.R.); AI-27659 and AI-29193 (to R.D.); and AI-27560 (to W.S.). Reprints or correspondence: Dr. Janet L. Lathey, Dept. of Pediatrics, University of California, San Diego, 9500 Gilman Dr., #0672, La Jolla, CA 92093-0672 ([email protected]). * Present affiliation: Abbott Laboratories, Abbott Park, Illinois.",

year = "1998",

doi = "10.1086/514250",

language = "English (US)",

volume = "177",

pages = "617--624",

journal = "Journal of Infectious Diseases",

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Lathey, JL, Hughes, MD, Fiscus, SA, Pi, T, Brooks Jackson, J, Rasheed, S, Elbeik, T, Reichman, R, Japour, A, D'Aquila, RT, Scott, W, Griffith, BP, Hammer, SM & Katzenstein, DA 1998, 'Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm³ (ACTG 175)', Journal of Infectious Diseases, vol. 177, no. 3, pp. 617-624. https://doi.org/10.1086/514250

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T1 - Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm3 (ACTG 175)

AU - Lathey, Janet L.

AU - Hughes, Michael D.

AU - Fiscus, Susan A.

AU - Pi, Timothy

AU - Brooks Jackson, J.

AU - Rasheed, Suraiya

AU - Elbeik, Tarek

AU - Reichman, Richard

AU - Japour, Anthony

AU - D'Aquila, Richard T.

AU - Scott, Walter

AU - Griffith, Brigitte P.

AU - Hammer, Scott M.

AU - Katzenstein, David A.

N1 - Funding Information: Received 20 May 1997; revised 29 September 1997. Presented in part: 4th Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 1997 (abstract 543). Informed consent was obtained from all study participants. The study followed the human experimentation guidelines of the US Department of Health and Human Services. Grant support: NIH: AI-27670, AI-38858, and AI-36214 (to J.L.L.); AI-25868, VC-006, and RR-00046 (to S.A.F.); AI-65304 (to J.B.J.); AI-27658 and RR-0004 (to R.R.); AI-27659 and AI-29193 (to R.D.); and AI-27560 (to W.S.). Reprints or correspondence: Dr. Janet L. Lathey, Dept. of Pediatrics, University of California, San Diego, 9500 Gilman Dr., #0672, La Jolla, CA 92093-0672 ([email protected]). * Present affiliation: Abbott Laboratories, Abbott Park, Illinois.

PY - 1998

Y1 - 1998

N2 - Virologic measurements are increasingly used to evaluate prognosis and treatment responses in human immunodeficiency virus (HIV) type 1 infection. Markers of HIV-1 replication, including infectious HIV-1 titer from peripheral blood mononuclear cells, serum HIV-1 p24 antigen, plasma HIV-1 RNA, CD4 cell numbers, and viral syncytium-inducing (SI) phenotype, were determined in 391 virology substudy participants in AIDS Clinical Trials Group study 175. The subjects had 200-500 CD4 cells/mm3. All markers of viral replication significantly correlated with one another and were inversely related to CD4 cell number. Disease progression to an AIDS-defining event or death or loss of >50% of CD4 cells was associated with infectious HIV-1 titer (P < .001), HIV-1 RNA (P < .001), and HIV-1 p24 antigen (P = .007). In multivariate proportional hazards models, p24 antigen was never significant when HIV-1 RNA level was included. In a model containing infectious HIV-1 titer (P = .038), HIV-1 RNA (P < .001), SI phenotype (P < .001), and CD4 cell number (P = .18), only the virologic parameters remained significantly associated with progression.

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