Variant translocations (9;11): Identification of the critical genetic rearrangement

Britte N. Harris, Elizabeth M. Davis, Michelle M. Le Beau*, Mitchell A. Bitter, Lynne S. Kaminer, Elaine R Morgan, Janet D. Rowley

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume30
Issue number1
DOIs
StatePublished - Jan 1988

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Harris, B. N., Davis, E. M., Le Beau, M. M., Bitter, M. A., Kaminer, L. S., Morgan, E. R., & Rowley, J. D. (1988). Variant translocations (9;11): Identification of the critical genetic rearrangement. Cancer Genetics and Cytogenetics, 30(1), 171-175. https://doi.org/10.1016/0165-4608(88)90108-2