Variant translocations (9;11): Identification of the critical genetic rearrangement

Britte N. Harris, Elizabeth M. Davis, Michelle M. Le Beau*, Mitchell A. Bitter, Lynne S. Kaminer, Elaine R Morgan, Janet D. Rowley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Jan 1988

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cancer Research


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