Variant translocations (9;11): Identification of the critical genetic rearrangement

Britte N. Harris; Elizabeth M. Davis; Michelle M. Le Beau; Mitchell A. Bitter; Lynne S. Kaminer; Elaine R Morgan; Janet D. Rowley

doi:10.1016/0165-4608(88)90108-2

Variant translocations (9;11): Identification of the critical genetic rearrangement

Britte N. Harris, Elizabeth M. Davis, Michelle M. Le Beau^*, Mitchell A. Bitter, Lynne S. Kaminer, Elaine R Morgan, Janet D. Rowley

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

Original language	English (US)
Pages (from-to)	171-175
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(88)90108-2
State	Published - Jan 1988

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Access to Document

10.1016/0165-4608(88)90108-2

Fingerprint Dive into the research topics of 'Variant translocations (9;11): Identification of the critical genetic rearrangement'. Together they form a unique fingerprint.

Cite this

Harris, B. N., Davis, E. M., Le Beau, M. M., Bitter, M. A., Kaminer, L. S., Morgan, E. R., & Rowley, J. D. (1988). Variant translocations (9;11): Identification of the critical genetic rearrangement. Cancer Genetics and Cytogenetics, 30(1), 171-175. https://doi.org/10.1016/0165-4608(88)90108-2

@article{f7fde3c09e1749b9994c2c7870a36438,

title = "Variant translocations (9;11): Identification of the critical genetic rearrangement",

abstract = "The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.",

author = "Harris, {Britte N.} and Davis, {Elizabeth M.} and {Le Beau}, {Michelle M.} and Bitter, {Mitchell A.} and Kaminer, {Lynne S.} and Morgan, {Elaine R} and Rowley, {Janet D.}",

year = "1988",

month = jan,

doi = "10.1016/0165-4608(88)90108-2",

language = "English (US)",

volume = "30",

pages = "171--175",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Variant translocations (9;11)

T2 - Identification of the critical genetic rearrangement

AU - Harris, Britte N.

AU - Davis, Elizabeth M.

AU - Le Beau, Michelle M.

AU - Bitter, Mitchell A.

AU - Kaminer, Lynne S.

AU - Morgan, Elaine R

AU - Rowley, Janet D.

PY - 1988/1

Y1 - 1988/1

N2 - The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

AB - The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

UR - http://www.scopus.com/inward/record.url?scp=0023857752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023857752&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(88)90108-2

DO - 10.1016/0165-4608(88)90108-2

M3 - Article

C2 - 3422044

AN - SCOPUS:0023857752

VL - 30

SP - 171

EP - 175

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 1

ER -