Variant translocations (9;11): Identification of the critical genetic rearrangement

Britte N. Harris; Elizabeth M. Davis; Michelle M. Le Beau; Mitchell A. Bitter; Lynne S. Kaminer; Elaine R Morgan; Janet D. Rowley

doi:10.1016/0165-4608(88)90108-2

Variant translocations (9;11): Identification of the critical genetic rearrangement

Britte N. Harris, Elizabeth M. Davis, Michelle M. Le Beau^*, Mitchell A. Bitter, Lynne S. Kaminer, Elaine R Morgan, Janet D. Rowley

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

Original language	English (US)
Pages (from-to)	171-175
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(88)90108-2
State	Published - Jan 1988

Funding

Supported in part by U.S. Department of Energy contract DE-FG02-86ER60408, by PHS grant CA36910 from the National Cancer Institute, and by the University of Chicago Cancer Research Foundation (M. M. L., J. D. R.). M. M. L. is a Special Fellow of the Leukemia Society of America. The authors thank Deborah Gifford for help in the preparation of the manuscript.

ASJC Scopus subject areas

Genetics
Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-4608(88)90108-2

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title = "Variant translocations (9;11): Identification of the critical genetic rearrangement",

abstract = "The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.",

author = "Harris, {Britte N.} and Davis, {Elizabeth M.} and {Le Beau}, {Michelle M.} and Bitter, {Mitchell A.} and Kaminer, {Lynne S.} and Morgan, {Elaine R} and Rowley, {Janet D.}",

note = "Funding Information: Supported in part by U.S. Department of Energy contract DE-FG02-86ER60408, by PHS grant CA36910 from the National Cancer Institute, and by the University of Chicago Cancer Research Foundation (M. M. L., J. D. R.). M. M. L. is a Special Fellow of the Leukemia Society of America. The authors thank Deborah Gifford for help in the preparation of the manuscript.",

year = "1988",

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doi = "10.1016/0165-4608(88)90108-2",

language = "English (US)",

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T2 - Identification of the critical genetic rearrangement

AU - Harris, Britte N.

AU - Davis, Elizabeth M.

AU - Le Beau, Michelle M.

AU - Bitter, Mitchell A.

AU - Kaminer, Lynne S.

AU - Morgan, Elaine R

AU - Rowley, Janet D.

N1 - Funding Information: Supported in part by U.S. Department of Energy contract DE-FG02-86ER60408, by PHS grant CA36910 from the National Cancer Institute, and by the University of Chicago Cancer Research Foundation (M. M. L., J. D. R.). M. M. L. is a Special Fellow of the Leukemia Society of America. The authors thank Deborah Gifford for help in the preparation of the manuscript.

PY - 1988/1

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N2 - The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

AB - The t(9;11)(p22;q23) is a recurring abnormality in acute nonlymphocytic leukemia. The analysis of complex 9;11 translocations will aid in the identification of the conserved chromosomal junction or the critical genetic alteration created by the rearrangement; however, variant translocations involving chromosomes #9 and #11 have not been reported. We have identified such variants in two patients who had acute myelomonocytic leukemia and acute monocytic leukemia, characterized by a t(9;11;18)(p22;q23;q12) and a t(9;11;13)(p22;q23;q34), respectively. The conserved junction resulting from these rearrangements is created by the translocation of chromosomal material from 9p to 11q.

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Variant translocations (9;11): Identification of the critical genetic rearrangement

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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