Variation in definitions of urinary tract infections in spina bifida patients: A systematic review

Ramiro Jose Madden-Fuentes, Erin Rebekah McNamara, Jessica Catherine Lloyd, John Samuel Wiener, Jonathan Charles Routh, Patrick Casey Seed, Sherry Sedberry Ross*

*Corresponding author for this work

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

OBJECTIVE: Urinary tract infections (UTIs) are a common source of morbidity among children with spina bifida (SB) and are a frequently reported outcome in studies of this patient population. However, the criteria for a diagnosis of UTI are often not stated. We evaluated the literature on SB patients for the criteria that authors use to define parameters in reporting UTI outcomes. METHODS: Embase and Medline were queried with the medical subject heading terms 'spinal dysraphism,' 'myelomeningocele,' 'infection,' and 'urinary tract infection.' A second search with the exploded term 'spina bifida' and 'urinary tract infection' was performed. Original research studies reporting a UTI outcome in SB patients were included and evaluated by 2 independent reviewers for the presence of a UTI definition and diagnostic criteria. RESULTS: We identified 872 publications, of which 124 met inclusion criteria. Forty-five of 124 (36.3%) studies reporting UTI as an outcome provided a definition of UTI. Of 124 studies, 28 (22.6%) were published in pediatric journals and 69 (55.6%) in urology journals. A definition of UTI was provided in 11 (39.3%) and 26 (37.7%) studies, respectively. 'Fever, culture, and symptoms' defined a UTI in 17 of 45 studies. Journal category and presence of UTI definitions did not correlate (P = .71). CONCLUSIONS: Explicit definitions for UTI are heterogeneous and infrequently applied in studies of SB patients, limiting study reliability and estimates of true UTI rates in this population. Future studies will benefit from the development and application of a standard definition for UTI in this population. Pediatrics 2013;132:132-139.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalPediatrics
Volume132
Issue number1
DOIs
StatePublished - Jul 1 2013

Fingerprint

Spinal Dysraphism
Urinary Tract Infections
Medical Subject Headings
Pediatrics
Population
Meningomyelocele
Urology

Keywords

  • Myelomeningocele
  • Neurogenic bladder
  • Spinal dysraphism
  • Urinary tract infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Madden-Fuentes, R. J., McNamara, E. R., Lloyd, J. C., Wiener, J. S., Routh, J. C., Seed, P. C., & Ross, S. S. (2013). Variation in definitions of urinary tract infections in spina bifida patients: A systematic review. Pediatrics, 132(1), 132-139. https://doi.org/10.1542/peds.2013-0557
Madden-Fuentes, Ramiro Jose ; McNamara, Erin Rebekah ; Lloyd, Jessica Catherine ; Wiener, John Samuel ; Routh, Jonathan Charles ; Seed, Patrick Casey ; Ross, Sherry Sedberry. / Variation in definitions of urinary tract infections in spina bifida patients : A systematic review. In: Pediatrics. 2013 ; Vol. 132, No. 1. pp. 132-139.
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abstract = "OBJECTIVE: Urinary tract infections (UTIs) are a common source of morbidity among children with spina bifida (SB) and are a frequently reported outcome in studies of this patient population. However, the criteria for a diagnosis of UTI are often not stated. We evaluated the literature on SB patients for the criteria that authors use to define parameters in reporting UTI outcomes. METHODS: Embase and Medline were queried with the medical subject heading terms 'spinal dysraphism,' 'myelomeningocele,' 'infection,' and 'urinary tract infection.' A second search with the exploded term 'spina bifida' and 'urinary tract infection' was performed. Original research studies reporting a UTI outcome in SB patients were included and evaluated by 2 independent reviewers for the presence of a UTI definition and diagnostic criteria. RESULTS: We identified 872 publications, of which 124 met inclusion criteria. Forty-five of 124 (36.3{\%}) studies reporting UTI as an outcome provided a definition of UTI. Of 124 studies, 28 (22.6{\%}) were published in pediatric journals and 69 (55.6{\%}) in urology journals. A definition of UTI was provided in 11 (39.3{\%}) and 26 (37.7{\%}) studies, respectively. 'Fever, culture, and symptoms' defined a UTI in 17 of 45 studies. Journal category and presence of UTI definitions did not correlate (P = .71). CONCLUSIONS: Explicit definitions for UTI are heterogeneous and infrequently applied in studies of SB patients, limiting study reliability and estimates of true UTI rates in this population. Future studies will benefit from the development and application of a standard definition for UTI in this population. Pediatrics 2013;132:132-139.",
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Madden-Fuentes, RJ, McNamara, ER, Lloyd, JC, Wiener, JS, Routh, JC, Seed, PC & Ross, SS 2013, 'Variation in definitions of urinary tract infections in spina bifida patients: A systematic review', Pediatrics, vol. 132, no. 1, pp. 132-139. https://doi.org/10.1542/peds.2013-0557

Variation in definitions of urinary tract infections in spina bifida patients : A systematic review. / Madden-Fuentes, Ramiro Jose; McNamara, Erin Rebekah; Lloyd, Jessica Catherine; Wiener, John Samuel; Routh, Jonathan Charles; Seed, Patrick Casey; Ross, Sherry Sedberry.

In: Pediatrics, Vol. 132, No. 1, 01.07.2013, p. 132-139.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Variation in definitions of urinary tract infections in spina bifida patients

T2 - A systematic review

AU - Madden-Fuentes, Ramiro Jose

AU - McNamara, Erin Rebekah

AU - Lloyd, Jessica Catherine

AU - Wiener, John Samuel

AU - Routh, Jonathan Charles

AU - Seed, Patrick Casey

AU - Ross, Sherry Sedberry

PY - 2013/7/1

Y1 - 2013/7/1

N2 - OBJECTIVE: Urinary tract infections (UTIs) are a common source of morbidity among children with spina bifida (SB) and are a frequently reported outcome in studies of this patient population. However, the criteria for a diagnosis of UTI are often not stated. We evaluated the literature on SB patients for the criteria that authors use to define parameters in reporting UTI outcomes. METHODS: Embase and Medline were queried with the medical subject heading terms 'spinal dysraphism,' 'myelomeningocele,' 'infection,' and 'urinary tract infection.' A second search with the exploded term 'spina bifida' and 'urinary tract infection' was performed. Original research studies reporting a UTI outcome in SB patients were included and evaluated by 2 independent reviewers for the presence of a UTI definition and diagnostic criteria. RESULTS: We identified 872 publications, of which 124 met inclusion criteria. Forty-five of 124 (36.3%) studies reporting UTI as an outcome provided a definition of UTI. Of 124 studies, 28 (22.6%) were published in pediatric journals and 69 (55.6%) in urology journals. A definition of UTI was provided in 11 (39.3%) and 26 (37.7%) studies, respectively. 'Fever, culture, and symptoms' defined a UTI in 17 of 45 studies. Journal category and presence of UTI definitions did not correlate (P = .71). CONCLUSIONS: Explicit definitions for UTI are heterogeneous and infrequently applied in studies of SB patients, limiting study reliability and estimates of true UTI rates in this population. Future studies will benefit from the development and application of a standard definition for UTI in this population. Pediatrics 2013;132:132-139.

AB - OBJECTIVE: Urinary tract infections (UTIs) are a common source of morbidity among children with spina bifida (SB) and are a frequently reported outcome in studies of this patient population. However, the criteria for a diagnosis of UTI are often not stated. We evaluated the literature on SB patients for the criteria that authors use to define parameters in reporting UTI outcomes. METHODS: Embase and Medline were queried with the medical subject heading terms 'spinal dysraphism,' 'myelomeningocele,' 'infection,' and 'urinary tract infection.' A second search with the exploded term 'spina bifida' and 'urinary tract infection' was performed. Original research studies reporting a UTI outcome in SB patients were included and evaluated by 2 independent reviewers for the presence of a UTI definition and diagnostic criteria. RESULTS: We identified 872 publications, of which 124 met inclusion criteria. Forty-five of 124 (36.3%) studies reporting UTI as an outcome provided a definition of UTI. Of 124 studies, 28 (22.6%) were published in pediatric journals and 69 (55.6%) in urology journals. A definition of UTI was provided in 11 (39.3%) and 26 (37.7%) studies, respectively. 'Fever, culture, and symptoms' defined a UTI in 17 of 45 studies. Journal category and presence of UTI definitions did not correlate (P = .71). CONCLUSIONS: Explicit definitions for UTI are heterogeneous and infrequently applied in studies of SB patients, limiting study reliability and estimates of true UTI rates in this population. Future studies will benefit from the development and application of a standard definition for UTI in this population. Pediatrics 2013;132:132-139.

KW - Myelomeningocele

KW - Neurogenic bladder

KW - Spinal dysraphism

KW - Urinary tract infection

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