Variation in intraoperative and postoperative red blood cell transfusion in pediatric surgery

Anne Stey*, Charles D. Vinocur, R. Lawrence Moss, Bruce L. Hall, Mark E. Cohen, Kari Kraemer, Clifford Y. Ko, Brian D. Kenney

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


BACKGROUND Intraoperative and postoperative red blood cell (RBC) transfusions are relatively frequent events tracked in the American College of Surgeons' National Surgical Quality Improvement Program-Pediatric (ACS-NSQIP-P). This study sought to quantify variation in RBC transfusion practices among hospitals. STUDY DESIGN AND METHODS This is an observational study of children older than 28 days who underwent a general, neurologic, urologic, otolaryngologic, plastic, or orthopedic operation at 50 hospitals in participating in the ACS-NSQIP-P during 2011 to 2012. The primary outcome was whether or not a RBC transfusion was administered from incision time to 72 hours postoperatively. Transfusions of fresh-frozen plasma, cryoprecipitate, and platelets were excluded from data abstraction due the rarity of their administration. A multivariate hierarchical risk-adjustment model estimated the risk-adjusted hospital RBC transfusion odds ratio (OR) and designated hospitals by transfusion practice. RESULTS The mean RBC transfusion rate was 1.5%. Five preoperative variables were associated with greater than threefold increased odds of having an intraoperative or postoperative RBC transfusion; young age; 29 days to 1 year (OR, 5.9; p < 0.001) and 1 to 2 years (OR, 3.4; p < 0.001); American Society of Anesthesiologists Class IV (OR, 3.2; p < 0.001); procedure linear risk (OR, 3.1; p < 0.001); preoperative septic shock (OR, 14.5; p < 0.001); and preoperative cardiopulmonary resuscitation (OR, 8.1; p < 0.001). Twenty-five hospitals had RBC transfusion practices significantly different than risk-adjusted mean (17 higher and eight lower). CONCLUSION Intraoperative and postoperative RBC transfusion practices vary widely among hospitals after controlling for patient and procedural characteristics.

Original languageEnglish (US)
Pages (from-to)666-672
Number of pages7
Issue number3
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Variation in intraoperative and postoperative red blood cell transfusion in pediatric surgery'. Together they form a unique fingerprint.

Cite this