Varicella–zoster virus infections in children infected with human immunodeficiency virus

Eugen Jura, Ellen G. Chadwick, Shelby H. Josephs, Sharon P. Steinberg, Ram Yogev, Anne A. Gershon, Keith M. Krasinski, William Borkowsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


Primary varicella-zoster (VZ) infection in eight children with perinatally acquired human immunodeficiency virus infection tended to be severe, prolonged, complicated by bacterial infections and in one case fatal. Depletion of CD4-lymphocytes was associated with chronic and recurrent VZ infection. In some patients convalescent VZ antibody titers were low and did not correlate with recurrence of VZ lesions. Administration of acyclovir appeared to be beneficial in suppressing VZ in human immunodeficiency virus-infected children with primary or recurrent VZ infection.

Original languageEnglish (US)
Pages (from-to)586-590
Number of pages5
JournalPediatric Infectious Disease Journal
Issue number9
StatePublished - Sep 1989


  • Varicella
  • human immunodeficiency virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases


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