Varicoceles in the pediatric and adolescent population: threat to future fertility?

Deborah L. Jacobson, Emilie K. Johnson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Determining the effect of varicoceles on future fertility is challenging owing to multiple issues in children/adolescents, including: limitations in obtaining and interpreting semen analyses; potential for unequal differential testicular growth during puberty regardless of varicocele presence; and the potential for a lengthy interval between surgical intervention for varicocele in adolescence and attempts at paternity. This review presents a summary and evaluation of the available evidence relating to future fertility among children and adolescents with varicoceles. Data relating to proxy fertility measures in children/adolescents, including testicular size asymmetry and semen analysis abnormalities, demonstrate that these proxy measures are imperfect predictors of future fertility. Two large, recently published series of adolescents undergoing varicocele treatment showed conflicting paternity outcomes. Pediatric and adolescent varicocele will remain a clinical conundrum, subject to both over- and under-treatment, until more definitive prospective data are available.

Original languageEnglish (US)
Pages (from-to)370-377
Number of pages8
JournalFertility and Sterility
Issue number3
StatePublished - Sep 2017


  • Fertility
  • pediatrics
  • varicocele

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


Dive into the research topics of 'Varicoceles in the pediatric and adolescent population: threat to future fertility?'. Together they form a unique fingerprint.

Cite this