Varus Thrust and Incident and Progressive Knee Osteoarthritis

Leena Sharma*, Alison Hsin-I Chang, Rebecca D. Jackson, Michael Nevitt, Kirsten C Moisio, Marc Hochberg, Charles Eaton, C. Kent Kwoh, Orit Almagor, Jane Cauley, Joan S Chmiel

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To determine if varus thrust, a bowing out of the knee during gait (i.e., the first appearance or worsening of varus alignment during stance), is associated with incident and progressive knee osteoarthritis (OA), we undertook an Osteoarthritis Initiative ancillary study. We further considered hypothesized associations adjusted for static alignment, anticipating some attenuation. Methods: Gait was observed for the presence of thrust by 1 of 2–3 examiners per study site at 4 sites. In eligible knees, incident OA was defined as subsequent incident Kellgren/Lawrence grade ≥2, whole- and partial-grade medial joint space narrowing (JSN), and annualized loss of joint space width (JSW); progression was defined as medial JSN and JSW loss. Outcome measures were assessed for up to 7 years of follow-up. Analyses were knee-level, using multivariable logistic and linear regression with generalized estimating equations to account for between-limb correlation. Results: The incident OA sample included 4,187 knees (2,610 persons); the progression sample included 3,421 knees (2,284 persons). In knees with OA, thrust was associated with progression as assessed by each outcome measure, with adjustment for age, sex, body mass index, and pain on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. In knees without OA, varus thrust was not associated with incident OA or other outcomes. After adjustment for alignment, the thrust–progression association was attenuated, but an independent association persisted for partial-grade JSN and JSW loss outcome models. WOMAC pain and alignment were consistently associated with all outcome measures. Within the stratum of varus knees, thrust was associated with an increased risk of progression. Conclusion: Varus thrust visualized during gait is associated with knee OA progression and should be a target of intervention development.

Original languageEnglish (US)
Pages (from-to)2136-2143
Number of pages8
JournalArthritis and Rheumatology
Volume69
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Knee Osteoarthritis
Joints
Knee
Osteoarthritis
Gait
Outcome Assessment (Health Care)
Pain
Ontario
Linear Models
Body Mass Index
Extremities
Logistic Models

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this

Sharma, Leena ; Chang, Alison Hsin-I ; Jackson, Rebecca D. ; Nevitt, Michael ; Moisio, Kirsten C ; Hochberg, Marc ; Eaton, Charles ; Kwoh, C. Kent ; Almagor, Orit ; Cauley, Jane ; Chmiel, Joan S. / Varus Thrust and Incident and Progressive Knee Osteoarthritis. In: Arthritis and Rheumatology. 2017 ; Vol. 69, No. 11. pp. 2136-2143.
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abstract = "Objective: To determine if varus thrust, a bowing out of the knee during gait (i.e., the first appearance or worsening of varus alignment during stance), is associated with incident and progressive knee osteoarthritis (OA), we undertook an Osteoarthritis Initiative ancillary study. We further considered hypothesized associations adjusted for static alignment, anticipating some attenuation. Methods: Gait was observed for the presence of thrust by 1 of 2–3 examiners per study site at 4 sites. In eligible knees, incident OA was defined as subsequent incident Kellgren/Lawrence grade ≥2, whole- and partial-grade medial joint space narrowing (JSN), and annualized loss of joint space width (JSW); progression was defined as medial JSN and JSW loss. Outcome measures were assessed for up to 7 years of follow-up. Analyses were knee-level, using multivariable logistic and linear regression with generalized estimating equations to account for between-limb correlation. Results: The incident OA sample included 4,187 knees (2,610 persons); the progression sample included 3,421 knees (2,284 persons). In knees with OA, thrust was associated with progression as assessed by each outcome measure, with adjustment for age, sex, body mass index, and pain on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. In knees without OA, varus thrust was not associated with incident OA or other outcomes. After adjustment for alignment, the thrust–progression association was attenuated, but an independent association persisted for partial-grade JSN and JSW loss outcome models. WOMAC pain and alignment were consistently associated with all outcome measures. Within the stratum of varus knees, thrust was associated with an increased risk of progression. Conclusion: Varus thrust visualized during gait is associated with knee OA progression and should be a target of intervention development.",
author = "Leena Sharma and Chang, {Alison Hsin-I} and Jackson, {Rebecca D.} and Michael Nevitt and Moisio, {Kirsten C} and Marc Hochberg and Charles Eaton and Kwoh, {C. Kent} and Orit Almagor and Jane Cauley and Chmiel, {Joan S}",
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Sharma, L, Chang, AH-I, Jackson, RD, Nevitt, M, Moisio, KC, Hochberg, M, Eaton, C, Kwoh, CK, Almagor, O, Cauley, J & Chmiel, JS 2017, 'Varus Thrust and Incident and Progressive Knee Osteoarthritis', Arthritis and Rheumatology, vol. 69, no. 11, pp. 2136-2143. https://doi.org/10.1002/art.40224

Varus Thrust and Incident and Progressive Knee Osteoarthritis. / Sharma, Leena; Chang, Alison Hsin-I; Jackson, Rebecca D.; Nevitt, Michael; Moisio, Kirsten C; Hochberg, Marc; Eaton, Charles; Kwoh, C. Kent; Almagor, Orit; Cauley, Jane; Chmiel, Joan S.

In: Arthritis and Rheumatology, Vol. 69, No. 11, 01.11.2017, p. 2136-2143.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Varus Thrust and Incident and Progressive Knee Osteoarthritis

AU - Sharma, Leena

AU - Chang, Alison Hsin-I

AU - Jackson, Rebecca D.

AU - Nevitt, Michael

AU - Moisio, Kirsten C

AU - Hochberg, Marc

AU - Eaton, Charles

AU - Kwoh, C. Kent

AU - Almagor, Orit

AU - Cauley, Jane

AU - Chmiel, Joan S

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objective: To determine if varus thrust, a bowing out of the knee during gait (i.e., the first appearance or worsening of varus alignment during stance), is associated with incident and progressive knee osteoarthritis (OA), we undertook an Osteoarthritis Initiative ancillary study. We further considered hypothesized associations adjusted for static alignment, anticipating some attenuation. Methods: Gait was observed for the presence of thrust by 1 of 2–3 examiners per study site at 4 sites. In eligible knees, incident OA was defined as subsequent incident Kellgren/Lawrence grade ≥2, whole- and partial-grade medial joint space narrowing (JSN), and annualized loss of joint space width (JSW); progression was defined as medial JSN and JSW loss. Outcome measures were assessed for up to 7 years of follow-up. Analyses were knee-level, using multivariable logistic and linear regression with generalized estimating equations to account for between-limb correlation. Results: The incident OA sample included 4,187 knees (2,610 persons); the progression sample included 3,421 knees (2,284 persons). In knees with OA, thrust was associated with progression as assessed by each outcome measure, with adjustment for age, sex, body mass index, and pain on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. In knees without OA, varus thrust was not associated with incident OA or other outcomes. After adjustment for alignment, the thrust–progression association was attenuated, but an independent association persisted for partial-grade JSN and JSW loss outcome models. WOMAC pain and alignment were consistently associated with all outcome measures. Within the stratum of varus knees, thrust was associated with an increased risk of progression. Conclusion: Varus thrust visualized during gait is associated with knee OA progression and should be a target of intervention development.

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