Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels

Natividad Villa, Liberty Walker, Claire E. Lindsell, Judith Gasson, M. Luisa Iruela-Arispe, Gerry Weinmaster*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

310 Scopus citations

Abstract

Mice with targeted mutations in genes required for Notch signal transduction die during embryogenesis, displaying overt signs of hemorrhage due to defects in their vascular development. Surprisingly, directed expression of a constitutively active form of Notch4 within mouse endothelial cells produces a similar vascular embryonic lethality. Moreover, patients with mutations in Notch3 exhibit the cerebral vascular disorder, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). These findings underscore the importance of Notch signaling in vascular development; however, they do not identify the specific functional defect. Here, we report that Notch1, Notch3, Notch4, Delta4, Jagged1 and Jagged2 are all expressed in arteries, but are not expressed by veins. These findings identify an aspect of Notch signaling that could contribute to the mechanism by which this pathway modulates vascular morphogenesis.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalMechanisms of Development
Volume108
Issue number1-2
DOIs
StatePublished - 2001

Keywords

  • Arterial blood vessels
  • Delta1
  • Delta3
  • Delta4
  • Endothelial cells
  • Expression pattern
  • Jagged1
  • Jagged2
  • Mouse
  • Notch signaling
  • Notch1
  • Notch2
  • Notch3
  • Notch4
  • Smooth muscle cells
  • Vascular development

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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