Vascular Growth Factors and Glomerular Disease

Christina S. Bartlett, Marie Jeansson, Susan E. Quaggin

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The glomerulus is a highly specialized microvascular bed that filters blood to form primary urinary filtrate. It contains four cell types: fenestrated endothelial cells, specialized vascular support cells termed podocytes, perivascular mesangial cells, and parietal epithelial cells. Glomerular cell-cell communication is critical for the development and maintenance of the glomerular filtration barrier. VEGF, ANGPT, EGF, SEMA3A, TGF-β, and CXCL12 signal in paracrine fashions between the podocytes, endothelium, and mesangium associated with the glomerular capillary bed to maintain filtration barrier function. In this review, we summarize the current understanding of these signaling pathways in the development and maintenance of the glomerulus and the progression of disease.

Original languageEnglish (US)
Pages (from-to)437-461
Number of pages25
JournalAnnual review of physiology
Volume78
DOIs
StatePublished - Feb 10 2016

Keywords

  • Angiopoietin
  • Endothelial cell
  • Podocyte
  • VEGF

ASJC Scopus subject areas

  • Physiology

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