Abstract
The glomerulus is a highly specialized microvascular bed that filters blood to form primary urinary filtrate. It contains four cell types: fenestrated endothelial cells, specialized vascular support cells termed podocytes, perivascular mesangial cells, and parietal epithelial cells. Glomerular cell-cell communication is critical for the development and maintenance of the glomerular filtration barrier. VEGF, ANGPT, EGF, SEMA3A, TGF-β, and CXCL12 signal in paracrine fashions between the podocytes, endothelium, and mesangium associated with the glomerular capillary bed to maintain filtration barrier function. In this review, we summarize the current understanding of these signaling pathways in the development and maintenance of the glomerulus and the progression of disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 437-461 |
| Number of pages | 25 |
| Journal | Annual review of physiology |
| Volume | 78 |
| DOIs | |
| State | Published - Feb 10 2016 |
Funding
C.S.B. is supported by NIH/NIDDK grant 5T32 DK007169. The laboratory of M.J. is funded by Swedish Research Council grant 521-2012-865; by a Department of Immunology, Genetics, and Pathology Young Investigator grant; by the Å ke Wiberg Foundation; and by the Magnus Bergvall Foundation. S.E.Q. holds the Charles H. Mayo Chair of Medicine at Northwestern University Feinberg School of Medicine and a Finnish Distinguished Professorship at Biocenter Oulu. The laboratory of S.E.Q. is funded by NIH/NHLBI grant HL1241200, by Canadian Institute of Health Research grants M0P62931 and M0P77756, by an E-rare Joint Translation Call (JTC 2011) for European Research Projects on Rare Diseases, and by Terry Fox Foundation grant 016002.
Keywords
- Angiopoietin
- Endothelial cell
- Podocyte
- VEGF
ASJC Scopus subject areas
- Physiology
