Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma

Mary J.C. Hendrix*, Elisabeth A. Seftor, Angela R. Hess, Richard E.B. Seftor

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

697 Scopus citations


The gene-expression profile of aggressive cutaneous and uveal melanoma cells resembles that of an undifferentiated, embryonic-like cell. The plasticity of certain types of cancer cell could explain their ability to mimic the activities of endothelial cells and to participate in processes such as neovascularization and the formation of a fluid-conducting, matrix-rich meshwork. This ability has been termed 'vasculogenic mimicry'. How does vasculogenic mimicry contribute to tumour progression, and can it be targeted by therapeutic agents?

Original languageEnglish (US)
Pages (from-to)411-421
Number of pages11
JournalNature Reviews Cancer
Issue number6
StatePublished - Jun 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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