Vasodilator Therapy for Pulmonary Hypertension

Lawrence Cotter; Michael Honey; Stuart Rich; Adeove Y. Olukotun; Lewis J. Rubin; Robert H. Peter; W. P. Klinke; John T. Reeves

doi:10.1056/NEJM198005293022213

Vasodilator Therapy for Pulmonary Hypertension

Lawrence Cotter, Michael Honey, Stuart Rich, Adeove Y. Olukotun, Lewis J. Rubin, Robert H. Peter, W. P. Klinke, John T. Reeves

Medicine, Cardiology Division

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

To the Editor: We have studied the clinical and hemodynamic effects of parenteral diazoxide in nine symptomatic patients with proved primary pulmonary hypertension, and the effects of oral diazoxide in seven of the same patients.¹ After incremental injections of a total of 300 to 600 mg of diazoxide into the pulmonary trunk, changes in pulmonary-artery mean pressure were insignificant. However, the pulmonary blood flow increased in every case by 1.2 to 3.2 liters per minute, rising from an average control level of 3.1 to an average of 5.4 liters per minute (P<0.001). The pulmonary vascular resistance likewise fell in every.

Original language	English (US)
Pages (from-to)	1260-1262
Number of pages	3
Journal	New England Journal of Medicine
Volume	302
Issue number	22
DOIs	https://doi.org/10.1056/NEJM198005293022213
State	Published - May 29 1980

ASJC Scopus subject areas

Medicine(all)

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title = "Vasodilator Therapy for Pulmonary Hypertension",

abstract = "To the Editor: We have studied the clinical and hemodynamic effects of parenteral diazoxide in nine symptomatic patients with proved primary pulmonary hypertension, and the effects of oral diazoxide in seven of the same patients.1 After incremental injections of a total of 300 to 600 mg of diazoxide into the pulmonary trunk, changes in pulmonary-artery mean pressure were insignificant. However, the pulmonary blood flow increased in every case by 1.2 to 3.2 liters per minute, rising from an average control level of 3.1 to an average of 5.4 liters per minute (P<0.001). The pulmonary vascular resistance likewise fell in every.",

author = "Lawrence Cotter and Michael Honey and Stuart Rich and Olukotun, {Adeove Y.} and Rubin, {Lewis J.} and Peter, {Robert H.} and Klinke, {W. P.} and Reeves, {John T.}",

year = "1980",

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day = "29",

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language = "English (US)",

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T1 - Vasodilator Therapy for Pulmonary Hypertension

AU - Cotter, Lawrence

AU - Honey, Michael

AU - Rich, Stuart

AU - Olukotun, Adeove Y.

AU - Rubin, Lewis J.

AU - Peter, Robert H.

AU - Klinke, W. P.

AU - Reeves, John T.

PY - 1980/5/29

Y1 - 1980/5/29

N2 - To the Editor: We have studied the clinical and hemodynamic effects of parenteral diazoxide in nine symptomatic patients with proved primary pulmonary hypertension, and the effects of oral diazoxide in seven of the same patients.1 After incremental injections of a total of 300 to 600 mg of diazoxide into the pulmonary trunk, changes in pulmonary-artery mean pressure were insignificant. However, the pulmonary blood flow increased in every case by 1.2 to 3.2 liters per minute, rising from an average control level of 3.1 to an average of 5.4 liters per minute (P<0.001). The pulmonary vascular resistance likewise fell in every.

AB - To the Editor: We have studied the clinical and hemodynamic effects of parenteral diazoxide in nine symptomatic patients with proved primary pulmonary hypertension, and the effects of oral diazoxide in seven of the same patients.1 After incremental injections of a total of 300 to 600 mg of diazoxide into the pulmonary trunk, changes in pulmonary-artery mean pressure were insignificant. However, the pulmonary blood flow increased in every case by 1.2 to 3.2 liters per minute, rising from an average control level of 3.1 to an average of 5.4 liters per minute (P<0.001). The pulmonary vascular resistance likewise fell in every.

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