Vasodilator Therapy for Pulmonary Hypertension

Lawrence Cotter, Michael Honey, Stuart Rich, Adeove Y. Olukotun, Lewis J. Rubin, Robert H. Peter, W. P. Klinke, John T. Reeves

Research output: Contribution to journalLetterpeer-review

8 Scopus citations


To the Editor: We have studied the clinical and hemodynamic effects of parenteral diazoxide in nine symptomatic patients with proved primary pulmonary hypertension, and the effects of oral diazoxide in seven of the same patients.1 After incremental injections of a total of 300 to 600 mg of diazoxide into the pulmonary trunk, changes in pulmonary-artery mean pressure were insignificant. However, the pulmonary blood flow increased in every case by 1.2 to 3.2 liters per minute, rising from an average control level of 3.1 to an average of 5.4 liters per minute (P<0.001). The pulmonary vascular resistance likewise fell in every.

Original languageEnglish (US)
Pages (from-to)1260-1262
Number of pages3
JournalNew England Journal of Medicine
Issue number22
StatePublished - May 29 1980

ASJC Scopus subject areas

  • General Medicine


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