TY - JOUR
T1 - VCAM-1 signals during lymphocyte migration
T2 - Role of reactive oxygen species
AU - Cook-Mills, Joan M.
N1 - Funding Information:
This research was supported by grants from the National Institutes of Health (R01 HL68171, R01AI40640, R29AI34585). We thank Tracy Deem and Dr. E. Charles Snow for review of this manuscript.
PY - 2002/12
Y1 - 2002/12
N2 - Vascular cell adhesion molecule-1 (VCAM-1) regulates leukocyte migration from the blood into tissues. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. Immediately following this migration, the endothelial cell-endothelial cell contact is re-established. VCAM-1 outside-in signals are mediated by NADPH oxidase production of reactive oxygen species and subsequently activation of matrix metalloproteinases. These signals are required for endothelial cell shape changes and leukocyte migration. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
AB - Vascular cell adhesion molecule-1 (VCAM-1) regulates leukocyte migration from the blood into tissues. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. Immediately following this migration, the endothelial cell-endothelial cell contact is re-established. VCAM-1 outside-in signals are mediated by NADPH oxidase production of reactive oxygen species and subsequently activation of matrix metalloproteinases. These signals are required for endothelial cell shape changes and leukocyte migration. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.
KW - Actin
KW - Cytokine
KW - Lymphocyte migration
KW - Matrix metalloproteinases
KW - VCAM-1 signals
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U2 - 10.1016/S0161-5890(02)00206-7
DO - 10.1016/S0161-5890(02)00206-7
M3 - Review article
C2 - 12431382
AN - SCOPUS:0036889639
VL - 39
SP - 499
EP - 508
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
IS - 9
ER -