VCAM-1 signals during lymphocyte migration: Role of reactive oxygen species

Joan M. Cook-Mills*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


Vascular cell adhesion molecule-1 (VCAM-1) regulates leukocyte migration from the blood into tissues. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. Immediately following this migration, the endothelial cell-endothelial cell contact is re-established. VCAM-1 outside-in signals are mediated by NADPH oxidase production of reactive oxygen species and subsequently activation of matrix metalloproteinases. These signals are required for endothelial cell shape changes and leukocyte migration. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

Original languageEnglish (US)
Pages (from-to)499-508
Number of pages10
JournalMolecular Immunology
Issue number9
StatePublished - Dec 2002


  • Actin
  • Cytokine
  • Lymphocyte migration
  • Matrix metalloproteinases
  • VCAM-1 signals

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology


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