@article{db6bb8dda2fa4b588f3b83d3d666fd0b,
title = "Venom characterization of the Brazilian Pampa snake Bothrops pubescens by top-down and bottom-up proteomics",
abstract = "The envenomation from the Bothrops genus is characterized by systemic and local effects caused by the main toxin families in the venom. In Bothrops pubescens venom we were able to identify 89 protein groups belonging to 13 toxin families with the bottom-up proteomics approach and 40 unique proteoforms belonging to 6 toxin families with the top-down proteomics approach. We also identified multi-proteoform complexes of dimeric L-amino acid oxidase using native top-down mass spectrometry.",
keywords = "Bothrops, Envenomation, L-amino acid Oxidase, Venomics",
author = "Rangel, {Darlene Lopes} and Melani, {Rafael D.} and Carvalho, {Evelise Leis} and Boldo, {Juliano Tomazzoni} and {Gomes dos Santos}, Tiago and Kelleher, {Neil L.} and Pinto, {Paulo Marcos}",
note = "Funding Information: This work was supported by the National Council for Scientific and Technological Development (CNPq-Brazil) , the Coordination for the Improvement of Higher Education Personnel (CAPES-Brazil) , the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Rio Grande do Sul (FAPERGS-Brazil) , the National Institute of Health in a visiting scholar program supported by a grant from the National Institute of General Medical Sciences P41 GM108569 (N.L.K.), and the NIH Office of Director award S10 OD025194 . D.L.R. received a research fellowship from CAPES-Brazil, and E.L.C. received a research fellowship from FAPERGS-Brazil. This is for Alice. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",
year = "2022",
month = dec,
doi = "10.1016/j.toxicon.2022.106937",
language = "English (US)",
volume = "220",
journal = "Toxicon",
issn = "0041-0101",
publisher = "Elsevier Limited",
}