Ventral intermediate thalamic stimulation in complex tremor syndromes

N. J. Diederich, L. Verhagen Metman, R. A. Bakay, F. Alesch

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Background/Aims: We report on deep brain stimulation (DBS) in the ventral intermediate part of the thalamus in 4 patients with complex tremor syndromes, 2 classified as Holmes tremor (HT) and 2 as thalamic tremor (TT). Results: Three out of 4 patients showed intraoperative improvement and underwent DBS implantation. One patient with TT without intraoperative improvement was not provided with an implant. A sustained beneficial effect was present after a follow-up ranging from 20 months to 7 years, although there was partial persistence of the intentional tremor and of proximal myoclonic-dystonic movements. The mean global clinical impression score was 2. In 1 HT patient the benefit persisted after battery failure. Conclusion: The study confirms that ventral intermediate thalamic DBS can provide long-term efficacy for HT and TT. While the patients experienced considerable and lasting functional improvement, the effect was incomplete and not all elements of their complex movement disorders were equally suppressed.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalStereotactic and Functional Neurosurgery
Issue number3
StatePublished - May 2008


  • Deep brain stimulation
  • Holmes tremor
  • Poststroke tremor thalamotomy
  • Thalamic tremor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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