Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics

Anne Beck, Florian Schlagenhauf, Torsten Wüstenberg, Jakob Hein, Thorsten Kienast, Thorsten Kahnt, Katharina Schmack, Claudia Hägele, Brian Knutson, Andreas Heinz, Jana Wrase*

*Corresponding author for this work

Research output: Contribution to journalArticle

268 Scopus citations

Abstract

Background: Alcohol dependence is often associated with impulsivity, which may be correlated with dysfunction of the brain reward system. We explored whether functional brain activation during anticipation of incentive stimuli is associated with impulsiveness in detoxified alcoholics and healthy control subjects. Methods: Nineteen detoxified male alcoholics and 19 age-matched healthy men participated in a functional magnetic resonance imaging (fMRI) study using a monetary incentive delay (MID) task, in which visual cues predicted that a rapid response to a subsequent target stimulus would either result in monetary gain, avoidance of monetary loss, or no consequence. Impulsivity was assessed with the Barratt Impulsiveness Scale-Version 10 (BIS-10). Results: Detoxified alcoholics showed reduced activation of the ventral striatum during anticipation of monetary gain relative to healthy control subjects. Low activation of the ventral striatum and anterior cingulate during gain anticipation was correlated with high impulsivity only in alcoholics, not in control subjects. Conclusions: This study suggests that reduced ventral striatal recruitment during anticipation of conventional rewards in alcoholics may be related to their increased impulsivity and indicate possibilities for enhanced treatment approaches in alcohol dependence.

Original languageEnglish (US)
Pages (from-to)734-742
Number of pages9
JournalBiological psychiatry
Volume66
Issue number8
DOIs
StatePublished - Oct 15 2009

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Keywords

  • Alcoholism
  • Dysfunction
  • FMRI
  • Impulsivity
  • Reward system
  • Ventral striatum

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Beck, A., Schlagenhauf, F., Wüstenberg, T., Hein, J., Kienast, T., Kahnt, T., Schmack, K., Hägele, C., Knutson, B., Heinz, A., & Wrase, J. (2009). Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics. Biological psychiatry, 66(8), 734-742. https://doi.org/10.1016/j.biopsych.2009.04.035