Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Peter Pytel; Aliya Husain; Ivan Moskowitz; Jai Raman; Heather MacLeod; Allen S. Anderson; Martin Burke; Elizabeth M. McNally

doi:10.1016/j.carpath.2008.09.004

Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Peter Pytel, Aliya Husain, Ivan Moskowitz, Jai Raman, Heather MacLeod, Allen S. Anderson, Martin Burke, Elizabeth M. McNally^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

Original language	English (US)
Pages (from-to)	e33-e36
Journal	Cardiovascular Pathology
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.carpath.2008.09.004
State	Published - Mar 2010

Funding

Keywords

Hypertrophic cardiomyopathy
Intramyocardial cell therapy
Stem cells
Transplant

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pathology and Forensic Medicine

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10.1016/j.carpath.2008.09.004

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title = "Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy",

abstract = "A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.",

keywords = "Hypertrophic cardiomyopathy, Intramyocardial cell therapy, Stem cells, Transplant",

author = "Peter Pytel and Aliya Husain and Ivan Moskowitz and Jai Raman and Heather MacLeod and Anderson, {Allen S.} and Martin Burke and McNally, {Elizabeth M.}",

year = "2010",

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T1 - Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

AU - Pytel, Peter

AU - Husain, Aliya

AU - Moskowitz, Ivan

AU - Raman, Jai

AU - MacLeod, Heather

AU - Anderson, Allen S.

AU - Burke, Martin

AU - McNally, Elizabeth M.

PY - 2010/3

Y1 - 2010/3

N2 - A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

AB - A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

KW - Hypertrophic cardiomyopathy

KW - Intramyocardial cell therapy

KW - Stem cells

KW - Transplant

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DO - 10.1016/j.carpath.2008.09.004

M3 - Article

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AN - SCOPUS:75149122968

SN - 1054-8807

VL - 19

SP - e33-e36

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

IS - 2

ER -

Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Abstract

Funding

Keywords

ASJC Scopus subject areas

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