Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy

Peter Pytel, Aliya Husain, Ivan Moskowitz, Jai Raman, Heather MacLeod, Allen S. Anderson, Martin Burke, Elizabeth M. McNally*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A 41-year-old male with cardiomyopathy from an inherited β myosin heavy-chain mutation underwent treatment for heart failure with intramyocardial cell transplantation. He received direct injections into his heart of autologous precursor cells isolated from his blood. He immediately suffered ventricular fibrillation. Although he was resuscitated, he experienced a prolonged downward course that prohibited his undergoing transplantation. His autopsy revealed marked fibrosis throughout the myocardium with areas of mononuclear cell infiltrate. This case highlights the potential adverse effects associated with intramyocardial therapy in the cardiomyopathic heart.

Original languageEnglish (US)
Pages (from-to)e33-e36
JournalCardiovascular Pathology
Volume19
Issue number2
DOIs
StatePublished - Mar 1 2010

Keywords

  • Hypertrophic cardiomyopathy
  • Intramyocardial cell therapy
  • Stem cells
  • Transplant

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cardiology and Cardiovascular Medicine

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