Ventricular fluid levels of chloramphenicol in infants

Ram Yogev, T. Williams

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Investigation of two infants suggested that peak ventricular fluid levels of chloramphenicol after intravenous administration were achieved after 3 h. The penetration of chloramphenicol into ventricular fluid may be unpredictable. In one patient, the peak ventricular fluid level was 57.5% of the peak serum level, while it was only 22.5% in the other patient. This observation may explain some of the past treatment failures when chloramphenicol was utilized in patients with gram-negative ventriculitis and meningitis.

Original languageEnglish (US)
Pages (from-to)7-8
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume16
Issue number1
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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