Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension

Elizabeth M. Mcnally; Peter M. Buttrick; Leslie A. Leinwand

doi:10.1093/nar/17.7.2753

Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension

Elizabeth M. Mcnally, Peter M. Buttrick, Leslie A. Leinwand^*

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Cardiac myosin heavy chain (MHC) isoform distribution has been shown to undergo changes during development, in response to hormonal stimuli, and during pathologic states like hypertension. We initiated a study of myosin light chain 1 (MLC1) expression in cardiac tissue to determine whether MLC1 undergoes changes similar to those seen for MHC. We isolated a full length cDNA for the predominant MLC1 sequence in rat hearts. This gene is expressed in ventricular tissue at much higher levels than in atrial tissue. Based on its expression pattern and sequence homology, this cDNA encodes the rat ventricular MLC1 and has been named RVMLC1. RVMLC1 is expressed at very low levels in cardiac tissue during early development and is expressed abundantly after birth and in adult hearts. The expression of RVMLC1 was found not to change in the hearts of rats with renovascular hypertension.

Original language	English (US)
Pages (from-to)	2753-2768
Number of pages	16
Journal	Nucleic acids research
Volume	17
Issue number	7
DOIs	https://doi.org/10.1093/nar/17.7.2753
State	Published - Apr 11 1989

ASJC Scopus subject areas

Genetics

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title = "Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension",

abstract = "Cardiac myosin heavy chain (MHC) isoform distribution has been shown to undergo changes during development, in response to hormonal stimuli, and during pathologic states like hypertension. We initiated a study of myosin light chain 1 (MLC1) expression in cardiac tissue to determine whether MLC1 undergoes changes similar to those seen for MHC. We isolated a full length cDNA for the predominant MLC1 sequence in rat hearts. This gene is expressed in ventricular tissue at much higher levels than in atrial tissue. Based on its expression pattern and sequence homology, this cDNA encodes the rat ventricular MLC1 and has been named RVMLC1. RVMLC1 is expressed at very low levels in cardiac tissue during early development and is expressed abundantly after birth and in adult hearts. The expression of RVMLC1 was found not to change in the hearts of rats with renovascular hypertension.",

author = "Mcnally, {Elizabeth M.} and Buttrick, {Peter M.} and Leinwand, {Leslie A.}",

note = "Funding Information: This work was supported by NIH GM29090 (L. A. L.). L. A. L. is an Established Investigator of the American Heart Association. E. M. M. is a trainee of the Medical Scientist Training Program (NIH T32GM7288). P. M. B. is a recipient of a NIH Clinical Investigator Award (HL-01552) .",

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Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension

Abstract

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