Ventricular parasystole and re-entry: Clinical-electrophysiological correlations

Donald H. Singer; R. Parameswaran; Frank T. Drake; Sheridan N. Meyers; Arthur A. DeBoer

doi:10.1016/0002-8703(74)90352-4

Ventricular parasystole and re-entry: Clinical-electrophysiological correlations

Donald H. Singer^*, R. Parameswaran, Frank T. Drake, Sheridan N. Meyers, Arthur A. DeBoer

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A 23-year-old patient with ventricular parasystole is described. Detailed analysis of ECG's obtained during 260 hours of Holter monitoring revealed a complex arrhythmia best explained in terms of the occurrence of manifest and concealed re-entry within the parasystolic focus. Re-entry, when manifest, resulted in premature beats coupled to the parasystolic beats, and brief runs of ventricular tachycardia. When concealed, re-entry produced an irregularity in the timing of the parasystolic beats. Re-entry within the parasystolic focus was also induced by sinus beats, giving rise to a pattern of bigeminy. Correlation with data obtained from glass microelectrode studies on canine Purkinje fibers and human cardiac tissue permits speculation regarding the electrophysiologic basis of "protection," and the possible interrelationships between parasystole and other types of ectopic ventricular rhythm.

Original language	English (US)
Pages (from-to)	79-87
Number of pages	9
Journal	American heart journal
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/0002-8703(74)90352-4
State	Published - Jul 1974

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0002-8703(74)90352-4

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title = "Ventricular parasystole and re-entry: Clinical-electrophysiological correlations",

abstract = "A 23-year-old patient with ventricular parasystole is described. Detailed analysis of ECG's obtained during 260 hours of Holter monitoring revealed a complex arrhythmia best explained in terms of the occurrence of manifest and concealed re-entry within the parasystolic focus. Re-entry, when manifest, resulted in premature beats coupled to the parasystolic beats, and brief runs of ventricular tachycardia. When concealed, re-entry produced an irregularity in the timing of the parasystolic beats. Re-entry within the parasystolic focus was also induced by sinus beats, giving rise to a pattern of bigeminy. Correlation with data obtained from glass microelectrode studies on canine Purkinje fibers and human cardiac tissue permits speculation regarding the electrophysiologic basis of {"}protection,{"} and the possible interrelationships between parasystole and other types of ectopic ventricular rhythm.",

author = "Singer, {Donald H.} and R. Parameswaran and Drake, {Frank T.} and Meyers, {Sheridan N.} and DeBoer, {Arthur A.}",

note = "Funding Information: From the Reingold ECG Center and the Departments of Medicine and Pharmacology and Surgery, Northwestern University Medical School, Chicago, Ill. Supported in part by Grants-in-Aid to Dr. Singer from the American Heart Association 68-875 and the Reingold J&ate. Received for publication May 31, 1973. Reprint requests to: Donald H. Singer, M.D., Northwestern Medical School, 303 E. Chicago Ave., Chicago, Ill. 60611. {\textquoteleft}Studies were carried out during Dr. Singer{\textquoteright}s tenure as an Established Inveetigator of the American Heart Association (67-155). **Dr. Parameawaran{\textquoteright}r current addrees is Albert Einstein Medical Center, Philadelphia, Pa.",

year = "1974",

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AU - Meyers, Sheridan N.

AU - DeBoer, Arthur A.

N1 - Funding Information: From the Reingold ECG Center and the Departments of Medicine and Pharmacology and Surgery, Northwestern University Medical School, Chicago, Ill. Supported in part by Grants-in-Aid to Dr. Singer from the American Heart Association 68-875 and the Reingold J&ate. Received for publication May 31, 1973. Reprint requests to: Donald H. Singer, M.D., Northwestern Medical School, 303 E. Chicago Ave., Chicago, Ill. 60611. ‘Studies were carried out during Dr. Singer’s tenure as an Established Inveetigator of the American Heart Association (67-155). **Dr. Parameawaran’r current addrees is Albert Einstein Medical Center, Philadelphia, Pa.

PY - 1974/7

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N2 - A 23-year-old patient with ventricular parasystole is described. Detailed analysis of ECG's obtained during 260 hours of Holter monitoring revealed a complex arrhythmia best explained in terms of the occurrence of manifest and concealed re-entry within the parasystolic focus. Re-entry, when manifest, resulted in premature beats coupled to the parasystolic beats, and brief runs of ventricular tachycardia. When concealed, re-entry produced an irregularity in the timing of the parasystolic beats. Re-entry within the parasystolic focus was also induced by sinus beats, giving rise to a pattern of bigeminy. Correlation with data obtained from glass microelectrode studies on canine Purkinje fibers and human cardiac tissue permits speculation regarding the electrophysiologic basis of "protection," and the possible interrelationships between parasystole and other types of ectopic ventricular rhythm.

AB - A 23-year-old patient with ventricular parasystole is described. Detailed analysis of ECG's obtained during 260 hours of Holter monitoring revealed a complex arrhythmia best explained in terms of the occurrence of manifest and concealed re-entry within the parasystolic focus. Re-entry, when manifest, resulted in premature beats coupled to the parasystolic beats, and brief runs of ventricular tachycardia. When concealed, re-entry produced an irregularity in the timing of the parasystolic beats. Re-entry within the parasystolic focus was also induced by sinus beats, giving rise to a pattern of bigeminy. Correlation with data obtained from glass microelectrode studies on canine Purkinje fibers and human cardiac tissue permits speculation regarding the electrophysiologic basis of "protection," and the possible interrelationships between parasystole and other types of ectopic ventricular rhythm.

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Ventricular parasystole and re-entry: Clinical-electrophysiological correlations

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