Versatile assembly of polymeric bicontinuous nanospheres via flash nanoprecipitation

Sharan Bobbala, Sean Allen, Nicholas Karabin, Evan Alexander Scott

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Polymeric bicontinuous nanospheres (BCNs) are considered polymeric analogues to lipid cubosomes, which possess high internal surface area and porosity. These structures can accommodate the simultaneous loading of a wide range of hydrophobic and hydrophilic molecules for diverse applications in controlled delivery. Although considered advantageous over lipid-based cubosomes in terms of stability, polymeric BCNs present numerous challenges for self-assembly and typically require the use of highly complex amphiphilic polymeric structures. In this study, a simple amphiphilic diblock copolymer, poly(ethylene glycol)17-block-poly(propylene sulfide)75 (PEG17-b-PPS75), was employed to self-assemble BCNs using the rapid and scalable technique of flash nanoprecipitation (FNP). Further, we characterized these nanocarriers both in vitro and in vivo for therapeutic delivery by benchmarking against polymersomes (PSs) (1,2).

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Bobbala, S., Allen, S., Karabin, N., & Scott, E. A. (2019). Versatile assembly of polymeric bicontinuous nanospheres via flash nanoprecipitation. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.