TY - GEN
T1 - Versatile assembly of polymeric bicontinuous nanospheres via flash nanoprecipitation
AU - Bobbala, Sharan
AU - Allen, Sean
AU - Karabin, Nicholas
AU - Scott, Evan Alexander
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Statement of Purpose: Polymeric bicontinuous nanospheres (BCNs) are considered polymeric analogues to lipid cubosomes, which possess high internal surface area and porosity. These structures can accommodate the simultaneous loading of a wide range of hydrophobic and hydrophilic molecules for diverse applications in controlled delivery. Although considered advantageous over lipid-based cubosomes in terms of stability, polymeric BCNs present numerous challenges for self-assembly and typically require the use of highly complex amphiphilic polymeric structures. In this study, a simple amphiphilic diblock copolymer, poly(ethylene glycol)17-block-poly(propylene sulfide)75 (PEG17-b-PPS75), was employed to self-assemble BCNs using the rapid and scalable technique of flash nanoprecipitation (FNP). Further, we characterized these nanocarriers both in vitro and in vivo for therapeutic delivery by benchmarking against polymersomes (PSs) (1,2).
AB - Statement of Purpose: Polymeric bicontinuous nanospheres (BCNs) are considered polymeric analogues to lipid cubosomes, which possess high internal surface area and porosity. These structures can accommodate the simultaneous loading of a wide range of hydrophobic and hydrophilic molecules for diverse applications in controlled delivery. Although considered advantageous over lipid-based cubosomes in terms of stability, polymeric BCNs present numerous challenges for self-assembly and typically require the use of highly complex amphiphilic polymeric structures. In this study, a simple amphiphilic diblock copolymer, poly(ethylene glycol)17-block-poly(propylene sulfide)75 (PEG17-b-PPS75), was employed to self-assemble BCNs using the rapid and scalable technique of flash nanoprecipitation (FNP). Further, we characterized these nanocarriers both in vitro and in vivo for therapeutic delivery by benchmarking against polymersomes (PSs) (1,2).
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M3 - Conference contribution
AN - SCOPUS:85065417608
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -