TY - JOUR
T1 - Vesicular disruption of myelin in autoimmune demyelination
AU - Dal Canto, Mauro C.
AU - Wiśniewski, Henryk M.
AU - Johnson, Anne B.
AU - Brostoff, Steven W.
AU - Raine, Cedric S.
N1 - Funding Information:
This investigation was supported in part by USPHS grants NS 08952, NS 03356 and NS 05275, grant 721-B-4 from the National Multiple Sclerosis Society, and a grant from the Alfred P. Sloan Foundation. Dr Raine is the recipient of a Research Career DevelopmentA ward (NS-70265) from the USPHS. * Present address: Department of Pathology (Neuropathology), Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, I11. 6061i , U.S.A. ** Present address: Department of Neurology, Medical Universityo f South Carolina, Charleston, S.C. 29401, U.S.A. *** Reprint requests to Dr. Raine.
PY - 1975/3
Y1 - 1975/3
N2 - A pattern of autoimmune demyelination in EAE and EAN has been described which was encountered consistently and was sometimes more common than the better known phenomenon of active stripping of myelin by macrophages. This pattern involved the rapid dissolution of myelin into a vesicular network which was later degraded by macrophages. It occurred early in the disease, was not accentuated perivascularly, and was usually associated with the presence of macrophages. The underlying mechanisms are not known but several alternatives have been discussed, viz., activity of locally released antibody, cytotoxic factors, or hydrolytic enzymes.
AB - A pattern of autoimmune demyelination in EAE and EAN has been described which was encountered consistently and was sometimes more common than the better known phenomenon of active stripping of myelin by macrophages. This pattern involved the rapid dissolution of myelin into a vesicular network which was later degraded by macrophages. It occurred early in the disease, was not accentuated perivascularly, and was usually associated with the presence of macrophages. The underlying mechanisms are not known but several alternatives have been discussed, viz., activity of locally released antibody, cytotoxic factors, or hydrolytic enzymes.
UR - http://www.scopus.com/inward/record.url?scp=0016669402&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016669402&partnerID=8YFLogxK
U2 - 10.1016/0022-510X(75)90251-8
DO - 10.1016/0022-510X(75)90251-8
M3 - Article
C2 - 1117307
AN - SCOPUS:0016669402
SN - 0022-510X
VL - 24
SP - 313
EP - 319
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 3
ER -