Vesicular disruption of myelin in autoimmune demyelination

Mauro C. Dal Canto, Henryk M. Wiśniewski, Anne B. Johnson, Steven W. Brostoff, Cedric S. Raine*

*Corresponding author for this work

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

A pattern of autoimmune demyelination in EAE and EAN has been described which was encountered consistently and was sometimes more common than the better known phenomenon of active stripping of myelin by macrophages. This pattern involved the rapid dissolution of myelin into a vesicular network which was later degraded by macrophages. It occurred early in the disease, was not accentuated perivascularly, and was usually associated with the presence of macrophages. The underlying mechanisms are not known but several alternatives have been discussed, viz., activity of locally released antibody, cytotoxic factors, or hydrolytic enzymes.

Original languageEnglish (US)
Pages (from-to)313-319
Number of pages7
JournalJournal of the Neurological Sciences
Volume24
Issue number3
DOIs
StatePublished - Mar 1975

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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