Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis

Bai Xin Ye, Xu Deng, Li Dong Shao, Ying Lu, Run Xiao, Yi Jie Liu, Yi Jin, Yin Yin Xie, Yan Zhao, Liu Fei Luo, Shun Ma, Ming Gao, Lian Ru Zhang, Juan He, Wei Na Zhang, Yi Chen, Cheng Feng Xia, Min Deng, Ting Xi Liu, Qin Shi Zhao*Sai Juan Chen, Zhu Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Interstitial leukocyte migration plays a critical role in inflammation and offers a therapeutic target for treating inflammation-associated diseases such as multiple sclerosis. Identifying small molecules to inhibit undesired leukocyte migration provides promise for the treatment of these disorders. In this study, we identified vibsanin B, a novel macrocyclic diterpenoid isolated from Viburnum odoratissimum Ker-Gawl, that inhibited zebrafish interstitial leukocyte migration using a transgenic zebrafish line (TG:zlyz-enhanced GFP). We found that vibsanin B preferentially binds to heat shock protein (HSP)90β. At the molecular level, inactivation of HSP90 can mimic vibsanin B's effect of inhibiting interstitial leukocyte migration. Furthermore, we demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS. In summary, vibsanin B is a novel lead compound that preferentially targets HSP90β and inhibits interstitial leukocyte migration, offering a promising drug lead for treating inflammation-associated diseases.

Original languageEnglish (US)
Pages (from-to)4489-4497
Number of pages9
JournalJournal of Immunology
Volume194
Issue number9
DOIs
StatePublished - May 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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