TY - JOUR
T1 - Victimization in Early Adolescence, Stress, and Depressive Symptoms among Aging Sexual Minority Men
T2 - Findings from the Multicenter AIDS Cohort Study
AU - Surkan, Pamela J.
AU - Wang, Ruibin
AU - Huang, Yuru
AU - Stall, Ron
AU - Plankey, Michael
AU - Teplin, Linda A.
AU - Wight, Richard G.
AU - Jacobson, Lisa P.
AU - Abraham, Alison G.
N1 - Funding Information:
The MACS is funded primarily by the National Institute of Allergy and Infectious Diseases, with additional co-funding from the National Cancer Institute, the National Institute on Drug Abuse, and the National Institute of Mental Health. Targeted supplemental funding for specific projects was also provided by the National Heart, Lung, and Blood Institute, and the National Institute on Deafness and Other Communication Disorders. MACS data collection is also supported by UL1-TR001079 ( JHU Institute for Clinical and Translational Research) from the National Center for Advancing Translational Sciences a component of the National Institutes of Health, and the National Institutes of Health Roadmap for Medical Research. This work was supported by the National Institute of Allergy and Infectious Diseases (Grant Nos. U01-AI35039, U01-AI35040, U01-AI35041, U01-AI35042, and UM1-AI35043), the National Institute of Mental Health (Grant No. R03-MH103961) and the Center for AIDS Research grant at Johns Hopkins Bloomberg School of Public Health.
Publisher Copyright:
© 2020, Mary Ann Liebert, Inc.
PY - 2020/4
Y1 - 2020/4
N2 - Purpose: We investigated the relation between adversities in early adolescence and risk of a depressive phenotype in adulthood, and whether stress in adulthood modified these associations. Methods: A total of 1138 men who have sex with men (MSM) participated in a Multicenter AIDS Cohort substudy in which they reported on adversities in early adolescence. Poisson regression estimated prevalence ratios (PRs) for associations between adversities and a depressive phenotype in adulthood. Stratified analyses examined the effects of stress in the last year on the depressive phenotype. Results: In adjusted models, men who were verbally insulted; threatened by physical violence; had an object thrown at them; or punched, kicked, or beaten were at higher risk of having a depressive phenotype in adulthood (for ≥1 time per month vs. never, PR = 1.50, 95% confidence interval [CI] = 1.15-1.96; PR = 1.84, 95% CI = 1.45-2.34; PR = 2.00, 95% CI = 1.51-2.66; or PR = 1.78, 95% CI = 1.35-2.34, respectively.) Being threatened with a weapon approached statistical significance (PR = 1.89, 95% CI = 0.96-3.72). Although higher stress was associated with depression overall, early adolescent victimization was only associated with depression among MSM not reporting high levels of stress in the last year (for ≥1 time per month vs. never, PR = 1.68, 95% CI = 1.09-2.59; PR = 2.11, 95% CI = 1.40-3.17; PR = 2.24, 95% CI = 1.24-4.03; PR = 1.98, 95% CI = 1.22-3.22, respectively). Conclusion: The attenuation of relationships between adversities and depression among men reporting high stress may suggest that adult stress overshadows long-term effects of early adolescent victimization on adult depression. Victimization in early adolescence may increase the risk of sustained depressive symptoms in mid- to later life, reinforcing the need for preventive strategies.
AB - Purpose: We investigated the relation between adversities in early adolescence and risk of a depressive phenotype in adulthood, and whether stress in adulthood modified these associations. Methods: A total of 1138 men who have sex with men (MSM) participated in a Multicenter AIDS Cohort substudy in which they reported on adversities in early adolescence. Poisson regression estimated prevalence ratios (PRs) for associations between adversities and a depressive phenotype in adulthood. Stratified analyses examined the effects of stress in the last year on the depressive phenotype. Results: In adjusted models, men who were verbally insulted; threatened by physical violence; had an object thrown at them; or punched, kicked, or beaten were at higher risk of having a depressive phenotype in adulthood (for ≥1 time per month vs. never, PR = 1.50, 95% confidence interval [CI] = 1.15-1.96; PR = 1.84, 95% CI = 1.45-2.34; PR = 2.00, 95% CI = 1.51-2.66; or PR = 1.78, 95% CI = 1.35-2.34, respectively.) Being threatened with a weapon approached statistical significance (PR = 1.89, 95% CI = 0.96-3.72). Although higher stress was associated with depression overall, early adolescent victimization was only associated with depression among MSM not reporting high levels of stress in the last year (for ≥1 time per month vs. never, PR = 1.68, 95% CI = 1.09-2.59; PR = 2.11, 95% CI = 1.40-3.17; PR = 2.24, 95% CI = 1.24-4.03; PR = 1.98, 95% CI = 1.22-3.22, respectively). Conclusion: The attenuation of relationships between adversities and depression among men reporting high stress may suggest that adult stress overshadows long-term effects of early adolescent victimization on adult depression. Victimization in early adolescence may increase the risk of sustained depressive symptoms in mid- to later life, reinforcing the need for preventive strategies.
KW - HIV
KW - MSM
KW - depression
KW - early adolescence
KW - stress victimization
UR - http://www.scopus.com/inward/record.url?scp=85083073145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083073145&partnerID=8YFLogxK
U2 - 10.1089/lgbt.2019.0036
DO - 10.1089/lgbt.2019.0036
M3 - Article
C2 - 32186958
AN - SCOPUS:85083073145
SN - 2325-8292
VL - 7
SP - 155
EP - 165
JO - LGBT Health
JF - LGBT Health
IS - 3
ER -
