Video-electrographic and clinical features in patients with ictal asystole

S. U. Schuele*, A. C. Bermeo, A. V. Alexopoulos, E. R. Locatelli, R. C. Burgess, D. S. Dinner, N. Foldvary-Schaefer

*Corresponding author for this work

Research output: Contribution to journalArticle

175 Scopus citations

Abstract

OBJECTIVE: Ictal asystole (IA) is a rare event mostly seen in patients with temporal lobe epilepsy (TLE) and a potential contributor to sudden unexplained death in epilepsy (SUDEP). Clinical and video-electroencephalographic findings associated with IA have not been described, and may be helpful in screening for high risk patients. METHODS: A database search was performed of 6,825 patients undergoing long-term video-EEG monitoring for episodes of IA. RESULTS: IA was recorded in 0.27% of all patients with epilepsy, eight with temporal (TLE), two with extratemporal (XTLE), and none with generalized epilepsy. In 8 out of 16 recorded events, all occurring in patients with TLE, seizures were associated with a sudden atonia on average 42 seconds into the typical semiology of a complex partial seizure. The loss of tone followed after a period of asystole usually lasting longer than 8 seconds and was associated with typical EEG changes seen otherwise with cerebral hypoperfusion. Clinical predisposing factors for IA including cardiovascular risk factors or baseline ECG abnormalities were not identified. CONCLUSION: Ictal asystole is a rare feature of patients with focal epilepsy. Delayed loss of tone is distinctly uncommon in patients with temporal lobe seizures, but may inevitably occur in patients with ictal asystole after a critical duration of cardiac arrest and cerebral hypoperfusion. Further cardiac monitoring in patients with temporal lobe epilepsy and a history of unexpected collapse and falls late in the course of a typical seizure may be warranted and can potentially help to prevent sudden unexplained death in epilepsy.

Original languageEnglish (US)
Pages (from-to)434-441
Number of pages8
JournalNeurology
Volume69
Issue number5
DOIs
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Clinical Neurology

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    Schuele, S. U., Bermeo, A. C., Alexopoulos, A. V., Locatelli, E. R., Burgess, R. C., Dinner, D. S., & Foldvary-Schaefer, N. (2007). Video-electrographic and clinical features in patients with ictal asystole. Neurology, 69(5), 434-441. https://doi.org/10.1212/01.wnl.0000266595.77885.7f