Viral and Cellular MicroRNAs as Determinants of Viral Pathogenesis and Immunity

Eva Gottwein, Bryan R. Cullen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

338 Scopus citations


MicroRNAs (miRNAs) have recently emerged as key posttranscriptional regulators of gene expression in multicellular eukaryotes. It is increasingly clear that miRNAs of both viral and cellular origin can positively or negatively influence viral replication. Viral miRNAs can directly alter host physiology, including components of the immune system, and host miRNAs can directly alter the virus life cycle. Here, we discuss what is known about how viral and cellular miRNAs influence viral replication and pathogenic potential through their regulation of viral mRNAs or by reshaping cellular gene expression.

Original languageEnglish (US)
Pages (from-to)375-387
Number of pages13
JournalCell Host and Microbe
Issue number6
StatePublished - Jun 12 2008

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology


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