Abstract
Purpose of Review: HIV rebound/remission after antiretroviral therapy (ART) interruption is likely influenced by (a) the size of the inducible replication-competent HIV reservoir and (b) factors in the host environment that influence immunological pressures on this reservoir. Identifying viral and/or host biomarkers of HIV rebound after ART cessation may improve the safety of treatment interruptions and our understanding of how the viral-host interplay results in post-treatment control. Here we review the predictive and functional significance of recently suggested viral and host biomarkers of time to viral rebound and post-treatment control following ART interruption. Recent Findings: There are currently no validated viral or host biomarkers of viral rebound; however, several biomarkers have been recently suggested. Summary: A combination of viral and host factors will likely be needed to predict viral rebound and to better understand the mechanisms contributing to post-treatment control of HIV, critical steps to developing a cure for HIV infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 217-233 |
| Number of pages | 17 |
| Journal | Current HIV/AIDS Reports |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2022 |
Funding
MA-M is funded by Bill & Melinda Gates Foundation, Campbell Foundation, the Foundation for AIDS Research (amfAR), and the NIH grants (R01AI165079, R01NS117458, R01DK123733, R01AG062383, and P30 AI 045008). MA-M and L.B.G are members of the investigation team of the NIH-funded BEAT-HIV Martin Delaney Collaboratory to cure HIV-1 infection (UM1AI164570). : LBG is funded by AIDS Clinical Trials Group (NWCS 539). Rachel E. Locke, Ph.D., provided critical comments and editing.
Keywords
- Biomarkers
- HIV
- Post-treatment controllers
- Viral rebound
ASJC Scopus subject areas
- Virology
- Infectious Diseases
