Viral membrane scission

Jeremy S. Rossman, Robert A. Lamb

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Virus budding is a complex, multistep process in which viral proteins make specific alterations in membrane curvature. Many different viral proteins can deform the membrane and form a budding virion, but very few can mediate membrane scission to complete the budding process. As a result, enveloped viruses have developed numerous ways of facilitating membrane scission, including hijacking host cellular scission machinery and expressing their own scission proteins. These proteins mediate scission in very different ways, though the biophysical mechanics underlying their actions may be similar. In this review, we explore the mechanisms of membrane scission and the ways in which enveloped viruses use these systems to mediate the release of budding virions.

Original languageEnglish (US)
Pages (from-to)551-569
Number of pages19
JournalAnnual Review of Cell and Developmental Biology
Volume29
DOIs
StatePublished - Oct 2013

Keywords

  • ESCRT
  • line tension
  • lipid phase segregation
  • membrane curvature
  • virus budding

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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