Virotherapy against malignant glioma stem cells

Mahua Dey, Ilya V. Ulasov, Maciej S. Lesniak*

*Corresponding author for this work

Research output: Contribution to journalShort survey

30 Scopus citations

Abstract

Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCancer Letters
Volume289
Issue number1
DOIs
StatePublished - Mar 1 2010

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Keywords

  • Adenovirus
  • Conditionally replicative virus
  • Glioblastoma multiforme
  • Malignant glioma
  • Stem cells
  • Virotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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