Virotherapy against malignant glioma stem cells

Mahua Dey; Ilya V. Ulasov; Maciej S. Lesniak

doi:10.1016/j.canlet.2009.04.045

Virotherapy against malignant glioma stem cells

Mahua Dey, Ilya V. Ulasov, Maciej S. Lesniak^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Cancer Letters
Volume	289
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.04.045
State	Published - Mar 1 2010

Keywords

Adenovirus
Conditionally replicative virus
Glioblastoma multiforme
Malignant glioma
Stem cells
Virotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2009.04.045

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title = "Virotherapy against malignant glioma stem cells",

abstract = "Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.",

keywords = "Adenovirus, Conditionally replicative virus, Glioblastoma multiforme, Malignant glioma, Stem cells, Virotherapy",

author = "Mahua Dey and Ulasov, {Ilya V.} and Lesniak, {Maciej S.}",

note = "Funding Information: This work was supported in part by the National Cancer Institute (R01-CA122930), the National Institute of Neurological Disorders and Stroke (K08-NS046430), The Alliance for Cancer Gene Therapy Young Investigator Award, and the American Cancer Society (RSG-07-276-01-MGO).",

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doi = "10.1016/j.canlet.2009.04.045",

language = "English (US)",

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journal = "Cancer Letters",

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TY - JOUR

T1 - Virotherapy against malignant glioma stem cells

AU - Dey, Mahua

AU - Ulasov, Ilya V.

AU - Lesniak, Maciej S.

N1 - Funding Information: This work was supported in part by the National Cancer Institute (R01-CA122930), the National Institute of Neurological Disorders and Stroke (K08-NS046430), The Alliance for Cancer Gene Therapy Young Investigator Award, and the American Cancer Society (RSG-07-276-01-MGO).

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

AB - Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

KW - Adenovirus

KW - Conditionally replicative virus

KW - Glioblastoma multiforme

KW - Malignant glioma

KW - Stem cells

KW - Virotherapy

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Virotherapy against malignant glioma stem cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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