Virotherapy against malignant glioma stem cells

Mahua Dey; Ilya V. Ulasov; Maciej S. Lesniak

doi:10.1016/j.canlet.2009.04.045

Virotherapy against malignant glioma stem cells

Mahua Dey, Ilya V. Ulasov, Maciej S. Lesniak^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Cancer Letters
Volume	289
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.04.045
State	Published - Mar 1 2010

Keywords

Adenovirus
Conditionally replicative virus
Glioblastoma multiforme
Malignant glioma
Stem cells
Virotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Virotherapy against malignant glioma stem cells",

abstract = "Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.",

keywords = "Adenovirus, Conditionally replicative virus, Glioblastoma multiforme, Malignant glioma, Stem cells, Virotherapy",

author = "Mahua Dey and Ulasov, {Ilya V.} and Lesniak, {Maciej S.}",

note = "Funding Information: This work was supported in part by the National Cancer Institute (R01-CA122930), the National Institute of Neurological Disorders and Stroke (K08-NS046430), The Alliance for Cancer Gene Therapy Young Investigator Award, and the American Cancer Society (RSG-07-276-01-MGO). ",

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AU - Ulasov, Ilya V.

AU - Lesniak, Maciej S.

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N2 - Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

AB - Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

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KW - Malignant glioma

KW - Stem cells

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