Virotherapy against malignant glioma stem cells

Mahua Dey; Ilya V. Ulasov; Maciej S. Lesniak

doi:10.1016/j.canlet.2009.04.045

Virotherapy against malignant glioma stem cells

Mahua Dey, Ilya V. Ulasov, Maciej S. Lesniak^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Short survey

30 Scopus citations

Abstract

Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Cancer Letters
Volume	289
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2009.04.045
State	Published - Mar 1 2010

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Keywords

Adenovirus
Conditionally replicative virus
Glioblastoma multiforme
Malignant glioma
Stem cells
Virotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

Dey, M., Ulasov, I. V., & Lesniak, M. S. (2010). Virotherapy against malignant glioma stem cells. Cancer Letters, 289(1), 1-10. https://doi.org/10.1016/j.canlet.2009.04.045

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Access to Document

10.1016/j.canlet.2009.04.045