Abstract
Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.
Original language | English (US) |
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Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | Cancer Letters |
Volume | 289 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 2010 |
Keywords
- Adenovirus
- Conditionally replicative virus
- Glioblastoma multiforme
- Malignant glioma
- Stem cells
- Virotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research