Abstract
Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Cancer Letters |
| Volume | 289 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 2010 |
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Keywords
- Adenovirus
- Conditionally replicative virus
- Glioblastoma multiforme
- Malignant glioma
- Stem cells
- Virotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
}
Virotherapy against malignant glioma stem cells. / Dey, Mahua; Ulasov, Ilya V.; Lesniak, Maciej S.
In: Cancer Letters, Vol. 289, No. 1, 01.03.2010, p. 1-10.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Virotherapy against malignant glioma stem cells
AU - Dey, Mahua
AU - Ulasov, Ilya V.
AU - Lesniak, Maciej S.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.
AB - Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.
KW - Adenovirus
KW - Conditionally replicative virus
KW - Glioblastoma multiforme
KW - Malignant glioma
KW - Stem cells
KW - Virotherapy
UR - http://www.scopus.com/inward/record.url?scp=75949120816&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75949120816&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2009.04.045
DO - 10.1016/j.canlet.2009.04.045
M3 - Short survey
C2 - 19643532
AN - SCOPUS:75949120816
VL - 289
SP - 1
EP - 10
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -