Virtual-detector synthetic aperture focusing technique with application in in-vivo photoacoustic microscopy

Meng Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica, Lihong V. Wang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In this study, we introduce a synthetic aperture focusing technique which employs a virtual detector concept, combined with coherence weighting, to extend the depth of focus for an in-vivo photoacoustic microscopy system. This technique treats the transducer's focal point as a virtual point detector of photoacoustic signals, delays adjacent scan lines relative to the virtual detector, and then sums the delayed signals to achieve focusing in the out-of-focus region. In addition, a coherence factor among the delayed signals for each synthesized imaging point is used as a weighting factor to further improve the focusing quality. Images of an Intralipid phantom containing a carbon fiber show how this technique improves the -6 dB lateral resolution from 49-379 μm to 46-53 μm and increases the SNR by 0-29 dB, depending on the distance from the ultrasonic focal point. In vivo experiments show that this technique also provides a clearer tumor-associated angiogenesis in the mouse's scalp. The extended depth of focus for the photoacoustic microscopy system enables 3D reconstruction of the vascular network for the study of tumor angiogenesis.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
DOIs
StatePublished - May 8 2006
Event7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006 - San Jose, CA, United States
Duration: Jan 22 2006Jan 26 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume6086
ISSN (Print)0277-786X

Other

Other7th Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - Photons Plus Ultrasound: Imaging and Sensing 2006
CountryUnited States
CitySan Jose, CA
Period1/22/061/26/06

Keywords

  • Coherence weighting
  • Depth of focus
  • Photoacoustic microscopy
  • Synthetic aperture focusing technique
  • Virtual detector

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Li, M. L., Zhang, H. F., Maslov, K., Stoica, G., & Wang, L. V. (2006). Virtual-detector synthetic aperture focusing technique with application in in-vivo photoacoustic microscopy. In Proceedings of SPIE - The International Society for Optical Engineering [60861F] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 6086). https://doi.org/10.1117/12.645115