Virtual electrodes and deexcitation: New insights into fibrillation induction and defibrillation

Igor R. Efimov; Richard A. Gray; Bradley J. Roth

doi:10.1111/j.1540-8167.2000.tb01805.x

Virtual electrodes and deexcitation: New insights into fibrillation induction and defibrillation

Igor R. Efimov^*, Richard A. Gray, Bradley J. Roth

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Previous models of fibrillation induction and defibrillation stressed the contribution of depolarization during the response of the heart to a shock. This article reviews recent evidence suggesting that comprehending the role of negative polarization (hyperpolarization) also is crucial for understanding the response to a shock. Negative polarization can 'deexcite' cardiac cells, creating regions of excitable tissue through which wavefronts can propagate. These wavefronts can result in new reentrant circuits, inducing fibrillation or causing defibrillation to fail. In addition, deexcitation can lead to rapid propagation through newly excitable regions, resulting in the elimination of excitable gaps soon after the shock and causing defibrillation to succeed.

Original language	English (US)
Pages (from-to)	339-353
Number of pages	15
Journal	Journal of cardiovascular electrophysiology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1111/j.1540-8167.2000.tb01805.x
State	Published - 2000

Keywords

Defibrillation
Electric shock
Sudden cardiac death
Ventricular fibrillation
Ventricular tachycardia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1111/j.1540-8167.2000.tb01805.x

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title = "Virtual electrodes and deexcitation: New insights into fibrillation induction and defibrillation",

abstract = "Previous models of fibrillation induction and defibrillation stressed the contribution of depolarization during the response of the heart to a shock. This article reviews recent evidence suggesting that comprehending the role of negative polarization (hyperpolarization) also is crucial for understanding the response to a shock. Negative polarization can 'deexcite' cardiac cells, creating regions of excitable tissue through which wavefronts can propagate. These wavefronts can result in new reentrant circuits, inducing fibrillation or causing defibrillation to fail. In addition, deexcitation can lead to rapid propagation through newly excitable regions, resulting in the elimination of excitable gaps soon after the shock and causing defibrillation to succeed.",

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AU - Efimov, Igor R.

AU - Gray, Richard A.

AU - Roth, Bradley J.

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AB - Previous models of fibrillation induction and defibrillation stressed the contribution of depolarization during the response of the heart to a shock. This article reviews recent evidence suggesting that comprehending the role of negative polarization (hyperpolarization) also is crucial for understanding the response to a shock. Negative polarization can 'deexcite' cardiac cells, creating regions of excitable tissue through which wavefronts can propagate. These wavefronts can result in new reentrant circuits, inducing fibrillation or causing defibrillation to fail. In addition, deexcitation can lead to rapid propagation through newly excitable regions, resulting in the elimination of excitable gaps soon after the shock and causing defibrillation to succeed.

KW - Defibrillation

KW - Electric shock

KW - Sudden cardiac death

KW - Ventricular fibrillation

KW - Ventricular tachycardia

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Virtual electrodes and deexcitation: New insights into fibrillation induction and defibrillation

Abstract

Keywords

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