Virus-like particles for drug delivery: a review of methods and applications

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Virus-like particles (VLPs) are self-assembling protein nanoparticles that have great promise as vectors for drug delivery. VLPs are derived from viruses but retain none of their infection or replication capabilities. These protein particles have defined surface chemistries, uniform sizes, and stability properties that make them attractive starting points for drug-delivery scaffolds. Here, we review recent advances in tailoring VLPs for drug-delivery applications, including VLP platform engineering approaches as well as methods for cargo loading, activation, and release. Finally, we highlight several successes using VLPs for drug delivery in model systems.

Original languageEnglish (US)
Article number102785
JournalCurrent Opinion in Biotechnology
Volume78
DOIs
StatePublished - Dec 2022

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biomedical Engineering

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