Abstract
Virus-like particles (VLPs) are self-assembling protein nanoparticles that have great promise as vectors for drug delivery. VLPs are derived from viruses but retain none of their infection or replication capabilities. These protein particles have defined surface chemistries, uniform sizes, and stability properties that make them attractive starting points for drug-delivery scaffolds. Here, we review recent advances in tailoring VLPs for drug-delivery applications, including VLP platform engineering approaches as well as methods for cargo loading, activation, and release. Finally, we highlight several successes using VLPs for drug delivery in model systems.
Original language | English (US) |
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Article number | 102785 |
Journal | Current Opinion in Biotechnology |
Volume | 78 |
DOIs | |
State | Published - Dec 2022 |
Funding
Portions of this project were funded by National Science Foundation Award CBET-2043973 to D.T.E. and B.C.I was supported by the Army Research Office Award W911NF-13-1-0383 .
ASJC Scopus subject areas
- Bioengineering
- Biotechnology
- Biomedical Engineering