TY - JOUR
T1 - Virus-like particles
T2 - The future of microbial factories and cell-free systems as platforms for vaccine development
AU - Rodríguez-Limas, William A.
AU - Sekar, Karthik
AU - Tyo, Keith E.J.
N1 - Funding Information:
This work has been funded by the National Science Foundation Graduate Research Fellowship (KS), the Achievement Rewards for College Scientist (ARCS) Foundation — Chicago Chapter (KS), the Chicago Biomedical Consortium with support from the Searle Funds at The Chicago Community Trust (WR), and Northwestern University .
PY - 2013/12
Y1 - 2013/12
N2 - Vaccines based on virus-like particles have proved their success in human health. More than 25 years after the approval of the first vaccine based on this technology, the substantial efforts to expand the range of applications and target diseases are beginning to bear fruit. The incursion of high-throughput screening technologies, combined with new developments in protein engineering and chemical coupling, have accelerated the development of systems capable of producing macrostructures useful for vaccinology, gene delivery, immunotherapy and bionanotechnology. This review summarizes the most recent developments in microbial cell factories and cell-free systems for virus-like particle production and discusses the future impact of this technology in human and animal health.
AB - Vaccines based on virus-like particles have proved their success in human health. More than 25 years after the approval of the first vaccine based on this technology, the substantial efforts to expand the range of applications and target diseases are beginning to bear fruit. The incursion of high-throughput screening technologies, combined with new developments in protein engineering and chemical coupling, have accelerated the development of systems capable of producing macrostructures useful for vaccinology, gene delivery, immunotherapy and bionanotechnology. This review summarizes the most recent developments in microbial cell factories and cell-free systems for virus-like particle production and discusses the future impact of this technology in human and animal health.
UR - http://www.scopus.com/inward/record.url?scp=84887620206&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887620206&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2013.02.008
DO - 10.1016/j.copbio.2013.02.008
M3 - Review article
C2 - 23481378
AN - SCOPUS:84887620206
SN - 0958-1669
VL - 24
SP - 1089
EP - 1093
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 6
ER -
