Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control

Alessandro Furlan, Gioele La Manno, Moritz Lübke, Martin Häring, Hind Abdo, Hannah Hochgerner, Jussi Kupari, Dmitry Usoskin, Matti S. Airaksinen, Guillermo Oliver, Sten Linnarsson*, Patrik Ernfors

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Despite the variety of physiological and target-related functions, little is known regarding the cellular complexity in the sympathetic ganglion. We explored the heterogeneity of mouse stellate and thoracic ganglia and found an unexpected variety of cell types. We identified specialized populations of nipple- and pilo-erector muscle neurons. These neurons extended axonal projections and were born among other neurons during embryogenesis, but remained unspecialized until target organogenesis occurred postnatally. Target innervation and cell-type specification was coordinated by an intricate acquisition of unique combinations of growth factor receptors and the initiation of expression of concomitant ligands by the nascent erector muscles. Overall, our results provide compelling evidence for a highly sophisticated organization of the sympathetic nervous system into discrete outflow channels that project to well-defined target tissues and offer mechanistic insight into how diversity and connectivity are established during development.

Original languageEnglish (US)
Pages (from-to)1331-1340
Number of pages10
JournalNature Neuroscience
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Nipples
Motor Neurons
Neurons
Muscles
Stellate Ganglion
Sympathetic Ganglia
Organogenesis
Growth Factor Receptors
Sympathetic Nervous System
Embryonic Development
Thorax
Ligands
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Furlan, A., La Manno, G., Lübke, M., Häring, M., Abdo, H., Hochgerner, H., ... Ernfors, P. (2016). Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nature Neuroscience, 19(10), 1331-1340. https://doi.org/10.1038/nn.4376
Furlan, Alessandro ; La Manno, Gioele ; Lübke, Moritz ; Häring, Martin ; Abdo, Hind ; Hochgerner, Hannah ; Kupari, Jussi ; Usoskin, Dmitry ; Airaksinen, Matti S. ; Oliver, Guillermo ; Linnarsson, Sten ; Ernfors, Patrik. / Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. In: Nature Neuroscience. 2016 ; Vol. 19, No. 10. pp. 1331-1340.
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Furlan, A, La Manno, G, Lübke, M, Häring, M, Abdo, H, Hochgerner, H, Kupari, J, Usoskin, D, Airaksinen, MS, Oliver, G, Linnarsson, S & Ernfors, P 2016, 'Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control', Nature Neuroscience, vol. 19, no. 10, pp. 1331-1340. https://doi.org/10.1038/nn.4376

Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. / Furlan, Alessandro; La Manno, Gioele; Lübke, Moritz; Häring, Martin; Abdo, Hind; Hochgerner, Hannah; Kupari, Jussi; Usoskin, Dmitry; Airaksinen, Matti S.; Oliver, Guillermo; Linnarsson, Sten; Ernfors, Patrik.

In: Nature Neuroscience, Vol. 19, No. 10, 01.10.2016, p. 1331-1340.

Research output: Contribution to journalArticle

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Furlan A, La Manno G, Lübke M, Häring M, Abdo H, Hochgerner H et al. Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Nature Neuroscience. 2016 Oct 1;19(10):1331-1340. https://doi.org/10.1038/nn.4376