Viscoelastic testing in benign hematologic disorders: Clinical perspectives and future implications of point-of-care testing to assess hemostatic competence

Jacob Speybroeck, Mathew Marsee, Faadil Shariff, Nuha Zackariya, Anne Grisoli, Stefani Vande Lune, Emilee E. Larson, Jordan Hatch, Ross McCauley, Faisal Shariff, John G. Aversa, Michael Son, Vanessa Agostini, Elena Campello, Paolo Simioni, Escaterina Scărlătescu, Hau Kwaan, Jan Hartmann, Dietmar Fries, Mark Walsh*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Viscoelastic tests (VETs) have been used routinely for liver transplantation, cardiac surgery, and trauma, but only recently have found clinical utility in benign hematologic disorders. Therefore, guidelines for diagnosis and treatment of these disorders based on viscoelastic variables have been adapted from the existing transplant, cardiothoracic surgery, and trauma resuscitation literature. As a result, diagnostic and therapeutic strategies for benign hematologic disorders utilizing VETs are not uniform. Accordingly, even though there has been a recent increase in the utilization of VET for the diagnosis and treatment of such disorders, the literature is still in its early stages. Analysis of point-of-care viscoelastic tracings from benign hematologic disorders has the potential to allow prompt recognition of disease and to guide patient-specific intervention. Here we present a review describing the application of VETs to benign hematologic disorders.

Original languageEnglish (US)
Pages (from-to)S101-S121
JournalTransfusion
Volume60
Issue numberS6
DOIs
StatePublished - Oct 1 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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